51,661 Results Found

Rising world population is expected to increase the demand for nitrogen fertilizers to improve crop yield and ensure food security. With existing challenges on low nutrient use efficiency (NUE) of urea and its environmental concerns, controlled relea...

Although analytical solutions for the problem of diffusion-controlled drug release from uniform formulations of simple geometries, like slabs, spheres, or cylinders, are well known, corresponding exact expressions for the average release times are no...

Sustained-release materials are increasingly being used in the delivery of oxidants for in situ chemical oxidation (ISCO) for groundwater remediation. Successful implementation of sustained-release materials depends on a clear understanding of the me...

The use of 3D printing techniques to control drug release has flourished in the past decade, although there is no generic solution that can be applied to the full range of drugs or solid dosage forms. The present study provides a new concept, using t...

Microcapsules are widely utilized in various applications to preserve active ingredients for prolonged durations while enabling controlled release. However, limited release of active ingredients often hampers their effectiveness in daily-use products...

This article attempts to develop hydrogel systems containing two polymers, chitosan and methylcellulose, with somatotropin as the active substance. The aim of the study was to obtain a hydrogel preparation for the skin that releases a sufficient amou...

Extracellular nucleotides (e.g., ATP, ADP, UTP, UDP) released by inflammatory cells interact with specific purinergic P2 type receptors to modulate their recruitment and activation. The focus of this review is on stimuli and mechanisms of extracellul...

Polysaccharides are naturally occurring complex molecules with exceptional physicochemical properties and bioactivities. They originate from plant, animal, and microbial-based resources and processes and can be chemically modified. The biocompatibili...

Tacrolimus-modified release formulations allow for once-daily dosing, and adherence is better compared to the twice-daily immediate release formulation. When patients are switched from one formulation to another, variable changes in drug concentratio...

Sterile males of Aedes aegypti were released once a week for 8 weeks to evaluate the dispersal efficiency of ground and aerial drone release methods in a rural village of 26 Ha in southern Mexico. Indoor and outdoor BG-Sentinel traps were placed in 1...

Recent developments in the controlled-release fertilizer (CRF) have led to the new modern agriculture industry, also known as precision farming. Biopolymers as encapsulating agents for the production of controlled-release fertilizers have helped to o...

The replacement of common urea with controlled-release nitrogen fertilizer can improve rice yield and quality, but the effect of controlled-release nitrogen fertilizer on rice yield and quality at different release stages is still unclear. In this ex...

Context: Today’s vehicle development is focusing more and more on handling the vast amount of software and hardware inside the vehicle. The resulting planning and development of the software especially confronts original equipment manufacturers...

Traditional approaches to achieve sustained delivery of pharmaceutical peptides traditionally use co-excipients (e.g., microspheres and hydrogels). Here, we investigate the release of an amyloidogenic glucagon analogue (3474) from an aggregated state...

Drug delivery from cylindrical tablets of arbitrary dimensions is discussed here, using the analytical solution of diffusion equation. Utilizing dimensionless quantities, we show that the release profiles are determined by a unique parameter, represe...

Background: Although the surgical release of the sternocleidomastoid muscle (SCM) is required for residual congenital muscular torticollis (CMT), the surgical outcomes between bipolar and unipolar SCM release remained unclear. The purpose of the pres...

Their controlled release property is the most important feature of functional microcapsules and carriers. In this work, melamine resin shell fragrance microcapsules were fabricated in a non-ionic system, and their chemical structure, particle size, a...

Tramadol is a veterinary analgesic for dogs. In this study, the steady-state pharmacokinetics of a sustained-release (SR) tablet (Tramagetic OD^®) and immediate-release capsules (IR) were compared. In a crossover design, six dogs received five dos...

Controlled release of substance from polyelectrolyte microcapsules is a triggered degradation of the microcapsule membrane that is extensive enough to release the contained substances out into the environment. Membrane degradation can be a result of...

In this work, biodegradable polymers were melt compounded with urea phosphate to fabricate “smart fertilizers” for sustainable agriculture. Urea phosphate (UP) is typically applied as a water-soluble fertilizer to treat phosphorus deficie...

In this study, we present a method for prediction of the drug-release profile based on the physical mechanisms that can intervene in drug release from a drug-carrier. The application presented here incorporates the effects of drug concentration and R...

The article discusses the release process of doxorubicin hydrochloride (DOX) from multi-wall carbon nanotubes (MWCNTs). The studies described a probable mechanism of release and actions between the surface of functionalized MWCNTs and anticancer drug...

This work explores the unique features of magnetic-responsive hydrogels to obtain liposomal hydrogel delivery platforms capable of precise magnetically modulated drug release based on the mechanical responses of these hydrogels when exposed to an ext...

Fertilizers play an essential role in agriculture due to the rising food demand. However, high input fertilizer concentration and the non-controlled leaching of nutrients cause an unwanted increase in reactive, unassimilated nitrogen and induce envir...

A significant energy release over a short time is achieved in replicable experiments involving the interaction of deuterium gas with constantan specimens. The experiments were carried out in a gas chamber where the injected deuterium interacted with...

Biphasic drug delivery systems are used for quick release of a specific amount of drug for immediate amelioration of a patient’s state, followed by sustained release, to avoid repeated administration. This type of delivery is often necessary fo...

By functionalizing reduced graphene oxide with polydopamine, the production of a two-dimensional hydrophilicplatform with hydrophobic areas, suitable for the stabilization and slow and controlled release of hydrophilic and hydrophobic drugs, was real...

Controlled-release tablets offer several benefits, such as controlled release, odor masking, ease of use, stability, extended shelf life, and reduced production costs. This study developed combined curcumin controlled-release tablets (CCCTs) to incre...

Controlled release urea (CRU) is considered to enhance crop yields while alleviating negative environmental problems caused by the hazardous gas emissions that are associated with high concentrations of ammonium (NH₄⁺) and nitrate (NO₃⁻) in black soi...

After patent protection of original brand is over, there are a lot of generic products occurring on the pharmaceutical market. It may be the way to reduce the price, but on the other hand, one should expect the same quality and almost identity with o...

Internationally, introduced invasive species inflict incalculable damage on native species and primary production. In New Zealand, wallabies, which were introduced from Australia, are damaging the native and agricultural environments, and their range...

Carbon nanotube (CNT)/polymer nanocomposites have superior properties compared to the neat polymer matrix. They now are widely used in industry, but questions have been raised about the risks of such materials since CNTs can be toxic when inhaled. Fo...

Hydrogels are attractive biomaterials for the controlled release of various pharmaceuticals, due to their ability to embed biologically active moieties in a 3D polymer network. Among them, agarose-based hydrogels are an interesting, but still not ful...

In this paper we study the release of cargo from polymeric nano-carriers under shear. Vesicles formed by two star block polymers— $A_{12}{B}_6{C}_2$ ( $ABC$ ) and $A_{12}{B}_6{A}_2$ ( $ABA$ )—and one linear block copoly...

The goal of this research is to improve preparation of charcoal adducts in a manner suitable for cationic drug release, possibly using an eco-friendly procedure. Charcoal, widely commercialized for human ingestion, is oxidized by hydrogen peroxide in...

In this study, we used chitosan/sodium alginate hydrogel as a carrier to prepare berberine sustained-release capsule materials that can inhibit algae for a long time and safely. The preparation conditions of the material were optimized by the respons...

Polydopamine (PDA), being highly reactive in nature, has acquired great attention in multi-disciplinary fields. Owing to its fascinating properties, including its biocompatible, non-toxic and readily bio-degradative nature, we investigated the drug l...

Zero-order release formulations are designed to release a drug at a constant rate over a prolonged time, thus reducing systemic side effects and improving patience adherence to the therapy. Such formulations are traditionally complex to manufacture,...

Solid dosage forms based on hypromellose (HPMC) with prolonged/extended drug release are very important from the research and industrial viewpoint. In the present research, the influence of selected excipients on carvedilol release performance from H...

In this study, gellan gum (GG), a natural polysaccharide, was used to fabricate spherical porous beads suitable as sustained drug delivery systems for oral administration. GG was cross-linked with calcium ions to prepare polymeric beads. Rheological...

This study aimed to determine the influence of different emulsifiers or xanthan-emulsifier systems on the release of aroma compounds. Solid-phase microextraction (SPME) and GC-MS were used to study the effects of varying concentrations of xanthan gum...

A mathematical model for the reaction-diffusion equation is developed to describe the nutrient release profiles and degradation of poly(lactic acid) (PLA)-coated controlled-release fertilizer. A multi-diffusion model that consists of coupled partial...

In this study, SRPF with metastable KAlSiO₄ as the main slow-release substance was prepared by the sintering method using fly ash and K₂CO₃ as raw materials, and an orthogonal experiment was conducted to optimize the raw material ratio and preparatio...

To investigate the release characteristics of potassium during biomass combustion, experimental studies were conducted on three typical biomass fuels in a reactor with a fixed-bed system. The effects of fuel type, combustion temperature, exposure tim...

In this work, five different dextran-based cryogels for controlled drug release are investigated. Vitamin B12 was used as a model drug for in vitro release tests. Two different drug-loading procedures were adopted, leading to very different drug rele...

Inspired by the gradual collapse of carbon chain and the gradual release of organic elements into the external environment during the degradation of biodegradable polymers, a novel biodegradable polymer slow-release fertilizer containing nutrient nit...

In this research, a low molecular weight poly(lactic acid) (or PLA) synthesized from direct polycondensation was melt compounded with urea to formulate slow-release fertilizer (SRF). We studied the influence of the molecular weight (M_W) of PLA as a m...

Triaxial electrospinning was used to fabricate fiber membranes composed of polycaprolactone (PCL), poly(lactic-co-glycolide) (PLGA), and gelatin (GT), designed as carriers for curcumin (Cur) delivery. Here, synthetic polyesters acted as core and shel...

The local treatment of diseases by drug-eluting implants is a promising tool to enable successful therapy under potentially reduced systemic side effects. Especially, the highly flexible manufacturing technique of 3D printing provides the opportunity...

Polyacrylate/silica hybrid emulsions were prepared by blending aqueous silica nanoparticles with polyacrylate emulsion, which were used for coating urea granules. After incorporating 1.0 wt.% silica nanoparticles into polyacrylate emulsion, prelimina...