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Article

Drosophila Larval Models of Invasive Tumorigenesis for In Vivo Studies on Tumour/Peripheral Host Tissue Interactions during Cancer Cachexia

1
CRUK Beatson Institute, Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK
2
Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Glasgow G61 1QH, UK
*
Author to whom correspondence should be addressed.
Equally contributing authors.
Academic Editor: Giuseppe Damante
Int. J. Mol. Sci. 2021, 22(15), 8317; https://doi.org/10.3390/ijms22158317
Received: 28 June 2021 / Revised: 27 July 2021 / Accepted: 29 July 2021 / Published: 2 August 2021
(This article belongs to the Special Issue Basic and Translational Models of Cooperative Oncogenesis 2.0)
Cancer cachexia is a common deleterious paraneoplastic syndrome that represents an area of unmet clinical need, partly due to its poorly understood aetiology and complex multifactorial nature. We have interrogated multiple genetically defined larval Drosophila models of tumourigenesis against key features of human cancer cachexia. Our results indicate that cachectic tissue wasting is dependent on the genetic characteristics of the tumour and demonstrate that host malnutrition or tumour burden are not sufficient to drive wasting. We show that JAK/STAT and TNF-α/Egr signalling are elevated in cachectic muscle and promote tissue wasting. Furthermore, we introduce a dual driver system that allows independent genetic manipulation of tumour and host skeletal muscle. Overall, we present a novel Drosophila larval paradigm to study tumour/host tissue crosstalk in vivo, which may contribute to future research in cancer cachexia and impact the design of therapeutic approaches for this pathology. View Full-Text
Keywords: Drosophila larvae; Ras; Scribble; dual driver system; cancer cachexia Drosophila larvae; Ras; Scribble; dual driver system; cancer cachexia
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MDPI and ACS Style

Hodgson, J.A.; Parvy, J.-P.; Yu, Y.; Vidal, M.; Cordero, J.B. Drosophila Larval Models of Invasive Tumorigenesis for In Vivo Studies on Tumour/Peripheral Host Tissue Interactions during Cancer Cachexia. Int. J. Mol. Sci. 2021, 22, 8317. https://doi.org/10.3390/ijms22158317

AMA Style

Hodgson JA, Parvy J-P, Yu Y, Vidal M, Cordero JB. Drosophila Larval Models of Invasive Tumorigenesis for In Vivo Studies on Tumour/Peripheral Host Tissue Interactions during Cancer Cachexia. International Journal of Molecular Sciences. 2021; 22(15):8317. https://doi.org/10.3390/ijms22158317

Chicago/Turabian Style

Hodgson, Joseph A., Jean-Philippe Parvy, Yachuan Yu, Marcos Vidal, and Julia B. Cordero. 2021. "Drosophila Larval Models of Invasive Tumorigenesis for In Vivo Studies on Tumour/Peripheral Host Tissue Interactions during Cancer Cachexia" International Journal of Molecular Sciences 22, no. 15: 8317. https://doi.org/10.3390/ijms22158317

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