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S-Palmitoylation of Synaptic Proteins as a Novel Mechanism Underlying Sex-Dependent Differences in Neuronal Plasticity

1
Laboratory of Cell Biophysics, Nencki Institute of Experimental Biology, Polish Academy of Science, Pasteur Str. 3, 02-093 Warsaw, Poland
2
Faculty of Chemistry, University of Warsaw, Pasteura 1, 02-093 Warsaw, Poland
3
Department of Computer Science and Engineering, Jadvapur University, Kolkata 700032, India
4
Cellular Neurophysiology, Hannover Medical School, Carl-Neuberg Str. 1, 30625 Hannover, Germany
5
Department of Mental Health, University of Münster, Albert-Schweitzer-Campus 1/A9, 48149 Munster, Germany
*
Authors to whom correspondence should be addressed.
These authors contributed equally.
Academic Editor: Seung Ho Jung
Int. J. Mol. Sci. 2021, 22(12), 6253; https://doi.org/10.3390/ijms22126253
Received: 9 April 2021 / Revised: 4 June 2021 / Accepted: 8 June 2021 / Published: 10 June 2021
(This article belongs to the Special Issue Omics-Based Molecular Mechanisms of Cognition under Stress)
Although sex differences in the brain are prevalent, the knowledge about mechanisms underlying sex-related effects on normal and pathological brain functioning is rather poor. It is known that female and male brains differ in size and connectivity. Moreover, those differences are related to neuronal morphology, synaptic plasticity, and molecular signaling pathways. Among different processes assuring proper synapse functions are posttranslational modifications, and among them, S-palmitoylation (S-PALM) emerges as a crucial mechanism regulating synaptic integrity. Protein S-PALM is governed by a family of palmitoyl acyltransferases, also known as DHHC proteins. Here we focused on the sex-related functional importance of DHHC7 acyltransferase because of its S-PALM action over different synaptic proteins as well as sex steroid receptors. Using the mass spectrometry-based PANIMoni method, we identified sex-dependent differences in the S-PALM of synaptic proteins potentially involved in the regulation of membrane excitability and synaptic transmission as well as in the signaling of proteins involved in the structural plasticity of dendritic spines. To determine a mechanistic source for obtained sex-dependent changes in protein S-PALM, we analyzed synaptoneurosomes isolated from DHHC7-/- (DHHC7KO) female and male mice. Our data showed sex-dependent action of DHHC7 acyltransferase. Furthermore, we revealed that different S-PALM proteins control the same biological processes in male and female synapses. View Full-Text
Keywords: posttranslational modifications; palmitoylation; sexes; proteomics; synapses; synaptic plasticity; DHHC7 posttranslational modifications; palmitoylation; sexes; proteomics; synapses; synaptic plasticity; DHHC7
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MDPI and ACS Style

Zaręba-Kozioł, M.; Bartkowiak-Kaczmarek, A.; Roszkowska, M.; Bijata, K.; Figiel, I.; Halder, A.K.; Kamińska, P.; Müller, F.E.; Basu, S.; Zhang, W.; Ponimaskin, E.; Włodarczyk, J. S-Palmitoylation of Synaptic Proteins as a Novel Mechanism Underlying Sex-Dependent Differences in Neuronal Plasticity. Int. J. Mol. Sci. 2021, 22, 6253. https://doi.org/10.3390/ijms22126253

AMA Style

Zaręba-Kozioł M, Bartkowiak-Kaczmarek A, Roszkowska M, Bijata K, Figiel I, Halder AK, Kamińska P, Müller FE, Basu S, Zhang W, Ponimaskin E, Włodarczyk J. S-Palmitoylation of Synaptic Proteins as a Novel Mechanism Underlying Sex-Dependent Differences in Neuronal Plasticity. International Journal of Molecular Sciences. 2021; 22(12):6253. https://doi.org/10.3390/ijms22126253

Chicago/Turabian Style

Zaręba-Kozioł, Monika; Bartkowiak-Kaczmarek, Anna; Roszkowska, Matylda; Bijata, Krystian; Figiel, Izabela; Halder, Anup K.; Kamińska, Paulina; Müller, Franziska E.; Basu, Subhadip; Zhang, Weiqi; Ponimaskin, Evgeni; Włodarczyk, Jakub. 2021. "S-Palmitoylation of Synaptic Proteins as a Novel Mechanism Underlying Sex-Dependent Differences in Neuronal Plasticity" Int. J. Mol. Sci. 22, no. 12: 6253. https://doi.org/10.3390/ijms22126253

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