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Omics-Based Molecular Mechanisms of Cognition under Stress

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".

Deadline for manuscript submissions: closed (31 December 2021) | Viewed by 3264

Special Issue Editors


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Guest Editor
U.S. Air Force Research Laboratory, The 711th Human Performance Wing/Human Effectiveness Directorate, Airman Bioengineering Division, USA
Interests: omics-approaches to molecular mechanisms of stress and cognition; stress molecular biology; memory process; psychoneuroimmunology; neuroimmunology; bioinformatics; network science

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Guest Editor
Department of Psychiatry and Behavioral Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
Interests: omics-approaches to molecular mechanisms of stress and cognition; stress molecular biology; memory process; psychoneuroimmunology; neuroimmunology; bioinformatics; network science

Special Issue Information

Dear Colleagues,

Chronic stress is now known to be associated with multiple disorders and diseases, including Alzheimer’s disease, depressive disorder, post-traumatic stress disorder, cognitive disorders. Until recently, how chronic stress affects the brain molecularly and functionally was investigated by analyzing the function of one or a small number of molecules in the brain of research animals or in the human blood. The development of scientific technologies, such as next-generation sequencing and advanced statistical and bioinformatics methods, has allowed scientists to explore and start to understand how chronic stress globally affects brain functions. In addition, these recently developed techniques and methods are greatly helping scientists decipher the omics-based molecular mechanisms of chronic stress-induced changes in cognitive functions including memory consolidation, memory retrieval, and learning processes. For this Special Issue, we encourage authors to submit original research and review articles to update our current understanding of omics-based (genomics, transcriptomics, epigenetics, proteomics, lipidomics, metabolomics) molecular mechanisms of cognitive processes under stress.

Dr. Seung Ho Jung
Dr. Redei Eva
Guest Editors

Manuscript Submission Information

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Keywords

  • chronic stress
  • post-traumatic stress disorder (PTSD)
  • cognition
  • memory
  • transcriptomics
  • proteomics
  • lipodomics
  • epigenetics
  • multi-omics
  • next-generation sequencing (NGS)

Published Papers (1 paper)

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Research

21 pages, 5431 KiB  
Article
S-Palmitoylation of Synaptic Proteins as a Novel Mechanism Underlying Sex-Dependent Differences in Neuronal Plasticity
by Monika Zaręba-Kozioł, Anna Bartkowiak-Kaczmarek, Matylda Roszkowska, Krystian Bijata, Izabela Figiel, Anup Kumar Halder, Paulina Kamińska, Franziska E. Müller, Subhadip Basu, Weiqi Zhang, Evgeni Ponimaskin and Jakub Włodarczyk
Int. J. Mol. Sci. 2021, 22(12), 6253; https://doi.org/10.3390/ijms22126253 - 10 Jun 2021
Cited by 6 | Viewed by 2790
Abstract
Although sex differences in the brain are prevalent, the knowledge about mechanisms underlying sex-related effects on normal and pathological brain functioning is rather poor. It is known that female and male brains differ in size and connectivity. Moreover, those differences are related to [...] Read more.
Although sex differences in the brain are prevalent, the knowledge about mechanisms underlying sex-related effects on normal and pathological brain functioning is rather poor. It is known that female and male brains differ in size and connectivity. Moreover, those differences are related to neuronal morphology, synaptic plasticity, and molecular signaling pathways. Among different processes assuring proper synapse functions are posttranslational modifications, and among them, S-palmitoylation (S-PALM) emerges as a crucial mechanism regulating synaptic integrity. Protein S-PALM is governed by a family of palmitoyl acyltransferases, also known as DHHC proteins. Here we focused on the sex-related functional importance of DHHC7 acyltransferase because of its S-PALM action over different synaptic proteins as well as sex steroid receptors. Using the mass spectrometry-based PANIMoni method, we identified sex-dependent differences in the S-PALM of synaptic proteins potentially involved in the regulation of membrane excitability and synaptic transmission as well as in the signaling of proteins involved in the structural plasticity of dendritic spines. To determine a mechanistic source for obtained sex-dependent changes in protein S-PALM, we analyzed synaptoneurosomes isolated from DHHC7-/- (DHHC7KO) female and male mice. Our data showed sex-dependent action of DHHC7 acyltransferase. Furthermore, we revealed that different S-PALM proteins control the same biological processes in male and female synapses. Full article
(This article belongs to the Special Issue Omics-Based Molecular Mechanisms of Cognition under Stress)
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