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Correction: Argenziano, M., et al. The Endocannabinoid System in Pediatric Inflammatory and Immune Diseases. Int. J. Mol. Sci. 2019, 20, 5875
 
 
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Endocannabinoid-Mediated Neuromodulation in the Olfactory Bulb: Functional and Therapeutic Significance

Department of Anatomy, Howard University College of Medicine, Washington, DC 20059, USA
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Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(8), 2850; https://doi.org/10.3390/ijms21082850
Received: 11 March 2020 / Revised: 15 April 2020 / Accepted: 17 April 2020 / Published: 19 April 2020
Endocannabinoid synthesis in the human body is naturally occurring and on-demand. It occurs in response to physiological and environmental stimuli, such as stress, anxiety, hunger, other factors negatively disrupting homeostasis, as well as the therapeutic use of the phytocannabinoid cannabidiol and recreational use of exogenous cannabis, which can lead to cannabis use disorder. Together with their specific receptors CB1R and CB2R, endocannabinoids are major components of endocannabinoid-mediated neuromodulation in a rapid and sustained manner. Extensive research on endocannabinoid function and expression includes studies in limbic system structures such as the hippocampus and amygdala. The wide distribution of endocannabinoids, their on-demand synthesis at widely different sites, their co-existence in specific regions of the body, their quantitative differences in tissue type, and different pathological conditions indicate their diverse biological functions that utilize specific and overlapping pathways in multiple organ systems. Here, we review emerging evidence of these pathways with a special emphasis on the role of endocannabinoids in decelerating neurodegenerative pathology through neural networks initiated by cells in the main olfactory bulb. View Full-Text
Keywords: Alzheimer’s Disease; endocannabinoids; neurodegeneration; neuromodulation; neural dysfunction; odor; olfactory bulb; olfactory system; synaptic plasticity Alzheimer’s Disease; endocannabinoids; neurodegeneration; neuromodulation; neural dysfunction; odor; olfactory bulb; olfactory system; synaptic plasticity
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MDPI and ACS Style

Bhatia-Dey, N.; Heinbockel, T. Endocannabinoid-Mediated Neuromodulation in the Olfactory Bulb: Functional and Therapeutic Significance. Int. J. Mol. Sci. 2020, 21, 2850. https://doi.org/10.3390/ijms21082850

AMA Style

Bhatia-Dey N, Heinbockel T. Endocannabinoid-Mediated Neuromodulation in the Olfactory Bulb: Functional and Therapeutic Significance. International Journal of Molecular Sciences. 2020; 21(8):2850. https://doi.org/10.3390/ijms21082850

Chicago/Turabian Style

Bhatia-Dey, Naina, and Thomas Heinbockel. 2020. "Endocannabinoid-Mediated Neuromodulation in the Olfactory Bulb: Functional and Therapeutic Significance" International Journal of Molecular Sciences 21, no. 8: 2850. https://doi.org/10.3390/ijms21082850

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