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Challenges to Successful Implementation of the Immune Checkpoint Inhibitors for Treatment of Glioblastoma

1
Department of Cancer Biology, Wake Forest School of Medicine, Winston Salem, NC 27157, USA
2
Brain Tumor Center of Excellence, Wake Forest Baptist Medical Center Comprehensive Cancer Center, Winston Salem, NC 27157, USA
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(8), 2759; https://doi.org/10.3390/ijms21082759
Received: 21 February 2020 / Revised: 8 April 2020 / Accepted: 14 April 2020 / Published: 16 April 2020
Glioblastoma (GBM) is the most common and aggressive malignant glioma, treatment of which has not improved significantly in many years. This is due to the unique challenges that GBM tumors present when designing and implementing therapies. Recently, immunotherapy in the form of immune checkpoint inhibition (ICI) has revolutionized the treatment of various malignancies. The application of immune checkpoint inhibition in GBM treatment has shown promising preclinical results. Unfortunately, this has met with little to no success in the clinic thus far. In this review, we will discuss the challenges presented by GBM tumors that likely limit the effect of ICI and discuss the approaches being tested to overcome these challenges. View Full-Text
Keywords: glioblastoma; immune checkpoint inhibitors; immunotherapy glioblastoma; immune checkpoint inhibitors; immunotherapy
MDPI and ACS Style

Sanders, S.; Debinski, W. Challenges to Successful Implementation of the Immune Checkpoint Inhibitors for Treatment of Glioblastoma. Int. J. Mol. Sci. 2020, 21, 2759.

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