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Article

Impact of Type 2 Diabetes Mellitus on Human Bone Marrow Stromal Cell Number and Phenotypic Characteristics

1
College of Medicine, Nursing and Health Science, School of Medicine, Regenerative Medicine Institute (REMEDI), National University of Ireland Galway (NUI Galway), H91 FD82 Galway, Ireland
2
Department of Trauma and Orthopaedics, Galway University Hospitals, H91 YR71 Galway, Ireland
3
Saolta University Healthcare Group, Galway University Hospital, H91 YR71 Galway, Ireland
4
CÚRAM Centre for Research in Medical Devices, College of Medicine, Nursing and Health Sciences, School of Medicine, NUI Galway, H91 FD82 Galway, Ireland
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(7), 2476; https://doi.org/10.3390/ijms21072476
Received: 6 March 2020 / Revised: 27 March 2020 / Accepted: 30 March 2020 / Published: 2 April 2020
Human bone marrow-derived mesenchymal stromal cells (MSCs) have been investigated in numerous disease settings involving impaired regeneration because of the crucial role they play in tissue maintenance and repair. Considering the number of comorbidities associated with type 2 diabetes mellitus (T2DM), the hypothesis that MSCs mediate these comorbidities via a reduction in their native maintenance and repair activities is an intriguing line of inquiry. Here, it is demonstrated that the number of bone marrow-derived MSCs in people with T2DM was reduced compared to that of age-matched control (AMC) donors and that this was due to a specific decrease in the number of MSCs with osteogenic capacity. There were no differences in MSC cell surface phenotype or in MSC expansion, differentiation, or angiogenic or migratory capacity from donors living with T2DM as compared to AMCs. These findings elucidate the basic biology of MSCs and their potential as mediators of diabetic comorbidities, especially osteopathies, and provide insight into donor choice for MSC-based clinical trials. This study suggests that any role of bone marrow MSCs as a mediator of T2DM comorbidity is likely due to a reduction in the osteoprogenitor population size and not due to a permanent alteration to the MSCs’ capacity to maintain tissue homeostasis through expansion and differentiation. View Full-Text
Keywords: type 2 diabetes mellitus; mesenchymal stem cells; mesenchymal stromal cells; adult stem cells; bone marrow stromal cells type 2 diabetes mellitus; mesenchymal stem cells; mesenchymal stromal cells; adult stem cells; bone marrow stromal cells
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MDPI and ACS Style

Cassidy, F.C.; Shortiss, C.; Murphy, C.G.; Kearns, S.R.; Curtin, W.; De Buitléir, C.; O’Brien, T.; Coleman, C.M. Impact of Type 2 Diabetes Mellitus on Human Bone Marrow Stromal Cell Number and Phenotypic Characteristics. Int. J. Mol. Sci. 2020, 21, 2476. https://doi.org/10.3390/ijms21072476

AMA Style

Cassidy FC, Shortiss C, Murphy CG, Kearns SR, Curtin W, De Buitléir C, O’Brien T, Coleman CM. Impact of Type 2 Diabetes Mellitus on Human Bone Marrow Stromal Cell Number and Phenotypic Characteristics. International Journal of Molecular Sciences. 2020; 21(7):2476. https://doi.org/10.3390/ijms21072476

Chicago/Turabian Style

Cassidy, Féaron C., Ciara Shortiss, Colin G. Murphy, Stephen R. Kearns, William Curtin, Ciara De Buitléir, Timothy O’Brien, and Cynthia M. Coleman 2020. "Impact of Type 2 Diabetes Mellitus on Human Bone Marrow Stromal Cell Number and Phenotypic Characteristics" International Journal of Molecular Sciences 21, no. 7: 2476. https://doi.org/10.3390/ijms21072476

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