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Could Intravenous Immunoglobulin Collected from Recovered Coronavirus Patients Protect against COVID-19 and Strengthen the Immune System of New Patients?

by Samir Jawhara 1,2
1
CNRS, UMR 8576 - UGSF—Unité de Glycobiologie Structurale et Fonctionnelle, INSERM U1285, F-59000 Lille, France
2
University of Lille, F-59000 Lille, France
Int. J. Mol. Sci. 2020, 21(7), 2272; https://doi.org/10.3390/ijms21072272 (registering DOI)
Received: 11 February 2020 / Revised: 23 March 2020 / Accepted: 23 March 2020 / Published: 25 March 2020
(This article belongs to the Section Molecular Immunology)
The emergence of the novel coronavirus in Wuhan, China, which causes severe respiratory tract infections in humans (COVID-19), has become a global health concern. Most coronaviruses infect animals but can evolve into strains that cross the species barrier and infect humans. At the present, there is no single specific vaccine or efficient antiviral therapy against COVID-19. Recently, we showed that intravenous immunoglobulin (IVIg) treatment reduces inflammation of intestinal epithelial cells and eliminates overgrowth of the opportunistic human fungal pathogen Candida albicans in the murine gut. Immunotherapy with IVIg could be employed to neutralize COVID-19. However, the efficacy of IVIg would be better if the immune IgG antibodies were collected from patients who have recovered from COVID-19 in the same city, or the surrounding area, in order to increase the chance of neutralizing the virus. These immune IgG antibodies will be specific against COVID-19 by boosting the immune response in newly infected patients. Different procedures may be used to remove or inactivate any possible pathogens from the plasma of recovered coronavirus patient derived immune IgG, including solvent/detergent, 60 °C heat-treatment, and nanofiltration. Overall, immunotherapy with immune IgG antibodies combined with antiviral drugs may be an alternative treatment against COVID-19 until stronger options such as vaccines are available. View Full-Text
Keywords: coronavirus; IVIg; immunotherapy; nCoV-2019; virus coronavirus; IVIg; immunotherapy; nCoV-2019; virus
MDPI and ACS Style

Jawhara, S. Could Intravenous Immunoglobulin Collected from Recovered Coronavirus Patients Protect against COVID-19 and Strengthen the Immune System of New Patients? Int. J. Mol. Sci. 2020, 21, 2272.

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