Extracellular Vesicles Function as Bioactive Molecular Transmitters in the Mammalian Oviduct: An Inspiration for Optimizing in Vitro Culture Systems and Improving Delivery of Exogenous Nucleic Acids during Preimplantation Embryonic Development
Abstract
:1. Introduction
2. General Aspects of EVs
3. Oviductosomes Participate in Communication between Oviduct and Embryos
4. Oviductosomes: Possibilities for Optimizing In Vitro Culture Systems
5. Oviductosomes: Potential Tools for Delivering Exogenous Nucleic Acids into Preimplantation Embryos
6. Challenges in Oviductosomes-Based Embryo Production
7. Conclusions
Funding
Conflicts of Interest
Abbreviations
EVs | Extracellular vesicles |
ESCRT | Endosomal sorting complexes required for transport |
OVS | Oviductosomes |
IVC | In vitro culture |
OVGP1 | Oviduct-specific glycoprotein precursor 1 |
ZP | Zona pellucida |
DNMT1 | DNA methyltransferase |
TPT1 | Tumor protein translationally-controlled 1 |
ROS | Reactive oxygen species |
RNAi | RNA interference |
ZGA | Zygotic gene activation |
GONAD | Genome editing via oviductal nucleic acid delivery |
ALI | Air–liquid-interphase |
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Fu, B.; Ma, H.; Liu, D. Extracellular Vesicles Function as Bioactive Molecular Transmitters in the Mammalian Oviduct: An Inspiration for Optimizing in Vitro Culture Systems and Improving Delivery of Exogenous Nucleic Acids during Preimplantation Embryonic Development. Int. J. Mol. Sci. 2020, 21, 2189. https://doi.org/10.3390/ijms21062189
Fu B, Ma H, Liu D. Extracellular Vesicles Function as Bioactive Molecular Transmitters in the Mammalian Oviduct: An Inspiration for Optimizing in Vitro Culture Systems and Improving Delivery of Exogenous Nucleic Acids during Preimplantation Embryonic Development. International Journal of Molecular Sciences. 2020; 21(6):2189. https://doi.org/10.3390/ijms21062189
Chicago/Turabian StyleFu, Bo, Hong Ma, and Di Liu. 2020. "Extracellular Vesicles Function as Bioactive Molecular Transmitters in the Mammalian Oviduct: An Inspiration for Optimizing in Vitro Culture Systems and Improving Delivery of Exogenous Nucleic Acids during Preimplantation Embryonic Development" International Journal of Molecular Sciences 21, no. 6: 2189. https://doi.org/10.3390/ijms21062189