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Article

Identification of Novel Genomic Regions and Superior Alleles Associated with Zn Accumulation in Wheat Using a Genome-Wide Association Analysis Method

1
Wheat Research Institute, Henan Academy of Agricultural Sciences, Zhengzhou 450002, China
2
College of Chemistry and Environment Engineering, Pingdingshan University, Pingdingshan 467000, China
3
Global Wheat Program, International Maize and Wheat Improvement Center (CIMMYT), Mexico, D.F. 06600, Mexico
4
College of Life Sciences, Zhengzhou University, Zhengzhou 450001, China
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2020, 21(6), 1928; https://doi.org/10.3390/ijms21061928
Received: 18 February 2020 / Revised: 7 March 2020 / Accepted: 9 March 2020 / Published: 11 March 2020
(This article belongs to the Collection Genetics and Molecular Breeding in Plants)
Micronutrient deficiencies, and especially zinc (Zn) deficiency, pose serious health problems to people who mainly depend on cereal-based diets. Here, we performed a genome-wide association study (GWAS) to detect the genetic basis of the Zn accumulation in wheat (Triticum aestivum L.) grains with a diversity panel of 207 bread wheat varieties. To uncover authentic quantitative trait loci (QTL) controlling Zn accumulation, the varieties were planted in three locations. In total, 29 unique loci associated with Zn grain accumulation were identified. Notably, seven non-redundant loci located on chromosomes 1B, 3B, 3D, 4A, 5A, 5B, and 7A, were detected at least in two environments. Of these quantitative trait loci (QTL), six coincided with known QTL or genes, whereas the highest effect QTL on chromosome 3D identified in this study was not reported previously. Searches of public databases revealed that the seven identified QTL coincided with seven putative candidate genes linked to Zn accumulation. Among these seven genes, NAC domain-containing protein gene (TraesCS3D02G078500) linked with the most significant single nucleotide polymorphism (SNP) AX-94729264 on chromosome 3D was relevant to metal accumulation in wheat grains. Results of this study provide new insights into the genetic architecture of Zn accumulation in wheat grains. View Full-Text
Keywords: wheat; zinc accumulation; GWAS; genetic loci; superior and inferior alleles wheat; zinc accumulation; GWAS; genetic loci; superior and inferior alleles
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MDPI and ACS Style

Zhou, Z.; Shi, X.; Zhao, G.; Qin, M.; Ibba, M.I.; Wang, Y.; Li, W.; Yang, P.; Wu, Z.; Lei, Z.; Wang, J. Identification of Novel Genomic Regions and Superior Alleles Associated with Zn Accumulation in Wheat Using a Genome-Wide Association Analysis Method. Int. J. Mol. Sci. 2020, 21, 1928. https://doi.org/10.3390/ijms21061928

AMA Style

Zhou Z, Shi X, Zhao G, Qin M, Ibba MI, Wang Y, Li W, Yang P, Wu Z, Lei Z, Wang J. Identification of Novel Genomic Regions and Superior Alleles Associated with Zn Accumulation in Wheat Using a Genome-Wide Association Analysis Method. International Journal of Molecular Sciences. 2020; 21(6):1928. https://doi.org/10.3390/ijms21061928

Chicago/Turabian Style

Zhou, Zhengfu, Xia Shi, Ganqing Zhao, Maomao Qin, Maria I. Ibba, Yahuan Wang, Wenxu Li, Pan Yang, Zhengqing Wu, Zhensheng Lei, and Jiansheng Wang. 2020. "Identification of Novel Genomic Regions and Superior Alleles Associated with Zn Accumulation in Wheat Using a Genome-Wide Association Analysis Method" International Journal of Molecular Sciences 21, no. 6: 1928. https://doi.org/10.3390/ijms21061928

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