Next Article in Journal / Special Issue
FASN Is a Biomarker Enriched in Malignant Glioma-Derived Extracellular Vesicles
Previous Article in Journal
Identification of Novel Genomic Regions and Superior Alleles Associated with Zn Accumulation in Wheat Using a Genome-Wide Association Analysis Method
Previous Article in Special Issue
Replication Protein A (RPA) Mediates Radio-Resistance of Glioblastoma Cancer Stem-Like Cells

Tumor Cell Invasion in Glioblastoma

Department of Neurology and Wilhelm Sander-NeuroOncology Unit, University Hospital Regensburg, 93053 Regensburg, Germany
Fraunhofer-Institute for Toxicology and Experimental Medicine, Division of Personalized Tumor Therapy, 93053 Regensburg, Germany
Experimental Medicine and Therapy Research, University of Regensburg, 93053 Regensburg, Germany
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(6), 1932;
Received: 13 February 2020 / Revised: 2 March 2020 / Accepted: 9 March 2020 / Published: 12 March 2020
(This article belongs to the Special Issue Advances of Molecular Biology and Translational Aspects in CNS Tumors)
Glioblastoma (GBM) is a particularly devastating tumor with a median survival of about 16 months. Recent research has revealed novel insights into the outstanding heterogeneity of this type of brain cancer. However, all GBM subtypes share the hallmark feature of aggressive invasion into the surrounding tissue. Invasive glioblastoma cells escape surgery and focal therapies and thus represent a major obstacle for curative therapy. This review aims to provide a comprehensive understanding of glioma invasion mechanisms with respect to tumor-cell-intrinsic properties as well as cues provided by the microenvironment. We discuss genetic programs that may influence the dissemination and plasticity of GBM cells as well as their different invasion patterns. We also review how tumor cells shape their microenvironment and how, vice versa, components of the extracellular matrix and factors from non-neoplastic cells influence tumor cell motility. We further discuss different research platforms for modeling invasion. Finally, we highlight the importance of accounting for the complex interplay between tumor cell invasion and treatment resistance in glioblastoma when considering new therapeutic approaches. View Full-Text
Keywords: glioma; glioblastoma; migration; invasion; microenvironment; genetic program glioma; glioblastoma; migration; invasion; microenvironment; genetic program
Show Figures

Figure 1

MDPI and ACS Style

Vollmann-Zwerenz, A.; Leidgens, V.; Feliciello, G.; Klein, C.A.; Hau, P. Tumor Cell Invasion in Glioblastoma. Int. J. Mol. Sci. 2020, 21, 1932.

AMA Style

Vollmann-Zwerenz A, Leidgens V, Feliciello G, Klein CA, Hau P. Tumor Cell Invasion in Glioblastoma. International Journal of Molecular Sciences. 2020; 21(6):1932.

Chicago/Turabian Style

Vollmann-Zwerenz, Arabel, Verena Leidgens, Giancarlo Feliciello, Christoph A. Klein, and Peter Hau. 2020. "Tumor Cell Invasion in Glioblastoma" International Journal of Molecular Sciences 21, no. 6: 1932.

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop