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EGR1 Transcription Factor is a Multifaceted Regulator of Matrix Production in Tendons and Other Connective Tissues

Laboratoire de Biologie du Développement, UMR7622, Institut Biologie Paris Seine, Sorbonne Université, CNRS, Inserm U1156, F75005 Paris, France
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Int. J. Mol. Sci. 2020, 21(5), 1664; https://doi.org/10.3390/ijms21051664
Received: 5 February 2020 / Revised: 24 February 2020 / Accepted: 25 February 2020 / Published: 28 February 2020
Although the transcription factor EGR1 is known as NGF1-A, TIS8, Krox24, zif/268, and ZENK, it still has many fewer names than biological functions. A broad range of signals induce Egr1 gene expression via numerous regulatory elements identified in the Egr1 promoter. EGR1 is also the target of multiple post-translational modifications, which modulate EGR1 transcriptional activity. Despite the myriad regulators of Egr1 transcription and translation, and the numerous biological functions identified for EGR1, the literature reveals a recurring theme of EGR1 transcriptional activity in connective tissues, regulating genes related to the extracellular matrix. Egr1 is expressed in different connective tissues, such as tendon (a dense connective tissue), cartilage and bone (supportive connective tissues), and adipose tissue (a loose connective tissue). Egr1 is involved in the development, homeostasis, and healing processes of these tissues, mainly via the regulation of extracellular matrix. In addition, Egr1 is often involved in the abnormal production of extracellular matrix in fibrotic conditions, and Egr1 deletion is seen as a target for therapeutic strategies to fight fibrotic conditions. This generic EGR1 function in matrix regulation has little-explored implications but is potentially important for tendon repair. View Full-Text
Keywords: connective tissues; tendon; adipose tissue; extracellular matrix; collagen; EGR1 connective tissues; tendon; adipose tissue; extracellular matrix; collagen; EGR1
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MDPI and ACS Style

Havis, E.; Duprez, D. EGR1 Transcription Factor is a Multifaceted Regulator of Matrix Production in Tendons and Other Connective Tissues. Int. J. Mol. Sci. 2020, 21, 1664. https://doi.org/10.3390/ijms21051664

AMA Style

Havis E, Duprez D. EGR1 Transcription Factor is a Multifaceted Regulator of Matrix Production in Tendons and Other Connective Tissues. International Journal of Molecular Sciences. 2020; 21(5):1664. https://doi.org/10.3390/ijms21051664

Chicago/Turabian Style

Havis, Emmanuelle, and Delphine Duprez. 2020. "EGR1 Transcription Factor is a Multifaceted Regulator of Matrix Production in Tendons and Other Connective Tissues" International Journal of Molecular Sciences 21, no. 5: 1664. https://doi.org/10.3390/ijms21051664

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