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Design of Polymeric and Biocompatible Delivery Systems by Dissolving Mesoporous Silica Templates
Review

Mesoporous Silica Nanoparticles for Targeting Subcellular Organelles

1
Departamento de Química en Ciencias Farmacéuticas, Instituto de Investigación Sanitaria Hospital 12 de Octubre i + 12, Universidad Complutense de Madrid, Plaza Ramón y Cajal s/n, 28040 Madrid, Spain
2
Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), 28029 Madrid, Spain
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2020, 21(24), 9696; https://doi.org/10.3390/ijms21249696
Received: 5 December 2020 / Revised: 15 December 2020 / Accepted: 16 December 2020 / Published: 18 December 2020
(This article belongs to the Special Issue Ordered Mesoporous Materials)
Current chemotherapy treatments lack great selectivity towards tumoral cells, which leads to nonspecific drug distribution and subsequent side effects. In this regard, the use of nanoparticles able to encapsulate and release therapeutic agents has attracted growing attention. In this sense, mesoporous silica nanoparticles (MSNs) have been widely employed as drug carriers owing to their exquisite physico-chemical properties. Because MSNs present a surface full of silanol groups, they can be easily functionalized to endow the nanoparticles with many different functionalities, including the introduction of moieties with affinity for the cell membrane or relevant compartments within the cell, thus increasing the efficacy of the treatments. This review manuscript will provide the state-of-the-art on MSNs functionalized for targeting subcellular compartments, focusing on the cytoplasm, the mitochondria, and the nucleus. View Full-Text
Keywords: mesoporous silica nanoparticles; targeting; subcellular targeting; endosomal escape; mitochondria; nucleus; nanomedicine; stimuli-responsive; drug delivery mesoporous silica nanoparticles; targeting; subcellular targeting; endosomal escape; mitochondria; nucleus; nanomedicine; stimuli-responsive; drug delivery
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MDPI and ACS Style

Gisbert-Garzarán, M.; Lozano, D.; Vallet-Regí, M. Mesoporous Silica Nanoparticles for Targeting Subcellular Organelles. Int. J. Mol. Sci. 2020, 21, 9696. https://doi.org/10.3390/ijms21249696

AMA Style

Gisbert-Garzarán M, Lozano D, Vallet-Regí M. Mesoporous Silica Nanoparticles for Targeting Subcellular Organelles. International Journal of Molecular Sciences. 2020; 21(24):9696. https://doi.org/10.3390/ijms21249696

Chicago/Turabian Style

Gisbert-Garzarán, Miguel, Daniel Lozano, and María Vallet-Regí. 2020. "Mesoporous Silica Nanoparticles for Targeting Subcellular Organelles" International Journal of Molecular Sciences 21, no. 24: 9696. https://doi.org/10.3390/ijms21249696

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