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Retraction: Han, H., et al. Contact/Release Coordinated Antibacterial Cotton Fabrics Coated with N-Halamine and Cationic Antibacterial Agent for Durable Bacteria-Killing Application. Int. J. Mol. Sci. 2020, 21, 6531
Article

Improving Stability of Tear Film Lipid Layer via Concerted Action of Two Drug Molecules: A Biophysical View

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Department of Cytology and Embryology, Faculty of Biology, University of Sofia, 1504 Sofia, Bulgaria
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J. Heyrovský Institute of Physical Chemistry, Czech Academy of Sciences, Dolejškova 3, 18223 Prague, Czech Republic
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iBB—Institute for Bioengineering and Biosciences, Complexo Interdisciplinar, IST, Universidade de Lisboa, 1649-004 Lisbon, Portugal
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SANTEN SAS, Novagali Innovation Center, 1, rue Pierre Fontaine, Bâtiment Genavenir IV, CEDEX, F-91458 Evry, France
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Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, 16610 Prague, Czech Republic
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(24), 9490; https://doi.org/10.3390/ijms21249490
Received: 10 November 2020 / Revised: 5 December 2020 / Accepted: 8 December 2020 / Published: 14 December 2020
(This article belongs to the Section Molecular Pharmacology)
The tear film at the ocular surface is covered by a thin layer of lipids. This oily phase stabilizes the film by decreasing its surface tension and improving its viscoelastic properties. Clinically, destabilization and rupture of the tear film are related to dry eye disease and are accompanied by changes in the quality and quantity of tear film lipids. In dry eye, eye drops containing oil-in-water emulsions are used for the supplementation of lipids and surface-active components to the tear film. We explore in detail the biophysical aspects of interactions of specific surface-active compounds, cetalkonium chloride and poloxamer 188, which are present in oil-in-water emulsions, with tear lipids. The aim is to better understand the macroscopically observed eye drops–tear film interactions by rationalizing them at the molecular level. To this end, we employ a multi-scale approach combining experiments on human meibomian lipid extracts, measurements using synthetic lipid films, and in silico molecular dynamics simulations. By combining these methods, we demonstrate that the studied compounds specifically interact with the tear lipid film enhancing its structure, surfactant properties, and elasticity. The observed effects are cooperative and can be further modulated by material packing at the tear–air interface. View Full-Text
Keywords: tear film; meibum; tear film lipid layer; dilatation rheology; fluorescence microscopy; molecular dynamics; Langmuir trough tear film; meibum; tear film lipid layer; dilatation rheology; fluorescence microscopy; molecular dynamics; Langmuir trough
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MDPI and ACS Style

Eftimov, P.; Olżyńska, A.; Melcrová, A.; Georgiev, G.A.; Daull, P.; Garrigue, J.-S.; Cwiklik, L. Improving Stability of Tear Film Lipid Layer via Concerted Action of Two Drug Molecules: A Biophysical View. Int. J. Mol. Sci. 2020, 21, 9490. https://doi.org/10.3390/ijms21249490

AMA Style

Eftimov P, Olżyńska A, Melcrová A, Georgiev GA, Daull P, Garrigue J-S, Cwiklik L. Improving Stability of Tear Film Lipid Layer via Concerted Action of Two Drug Molecules: A Biophysical View. International Journal of Molecular Sciences. 2020; 21(24):9490. https://doi.org/10.3390/ijms21249490

Chicago/Turabian Style

Eftimov, Petar, Agnieszka Olżyńska, Adéla Melcrová, Georgi A. Georgiev, Philippe Daull, Jean-Sebastien Garrigue, and Lukasz Cwiklik. 2020. "Improving Stability of Tear Film Lipid Layer via Concerted Action of Two Drug Molecules: A Biophysical View" International Journal of Molecular Sciences 21, no. 24: 9490. https://doi.org/10.3390/ijms21249490

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