Search Results (13,795)

Solanum torvum is an important medicinal and culinary vegetable with poor seed propagation, characterized by low germination and limited seed longevity. This study examined the effects of fruit maturity stage, storage temperature, duration, and endogenous hormonal profiles on seed germination. Fruits were harvested at three physiological maturity stages: matured green, ripe yellow, and overripe brown. Extracted seeds were stored in ambient (24–26 °C) and cold (3–8 °C) conditions for 24 weeks, with subsequent germination testing with 3 replicates per treatment. Endogenous abscisic acid (ABA) and gibberellic acid (GA) were quantified using HPLC-DAD to assess their association with germination behaviour. Seeds from ripe yellow fruits achieved the highest germination (95%), with a mean germination time of 12 days and a mean germination rate of 8%, identifying this stage as the optimal maturity stage for harvest. While total germination percentage was enhanced by an after-ripening effect during the first 16 weeks of ambient storage, other vigour parameters, including mean germination time and rate and synchronization began to decline thereafter. ABA and GA concentrations displayed treatment-dependent variation across maturity stages and storage conditions, with hormonal trends showing complex associations with dormancy release rather than consistent main effects. These findings indicate that harvesting Solanum torvum fruits at the ripe yellow stage and storing seeds under ambient conditions for up to 16 weeks, under the conditions evaluated in this study, provides a practical balance between dormancy alleviation and seed vigour, thereby improving short-term propagation efficiency. Full article

The paper presents the results of a study of linear wear of gas-flame and ion-plasma coatings of KNA-82 seals with an yttrium content of 0.5%, used in gas turbine engine assemblies, during physical modeling of their thermomechanical loading on small-sized samples. Tribotechnical tests were carried out in four stages, simulating the operating conditions of real gas turbine engines—from the first start-up with running-in of the coating cut-in areas to reaching a steady state with their service properties formed. The surface of the coatings was in contact with the ridges of triangular-shaped plates without heating (20 °C), at average heating (350–470 °C), after holding the samples at 1100 °C and average heating of 410–460 °C, and after grinding off the worn layer that had worn out after holding the samples at 1100 °C at average heating of 320–440 °C. Trends in the change in the linear ear of coatings and the formation of friction tracks caused by the uneven manifestation of the physical and mechanical properties of coatings, which are unevenly distributed throughout their body, were determined. It was found that both coatings tend to stabilize the wear process at certain mechanical pressures in the friction contact zone and only in the temperature range from 20 °C to 400 °C. These pressures range from 4 MPa to 6.7 MPa for gas-flame coatings and from 3 MPa to 4.2 MPa for ion-plasma coatings. It has been determined that within the depth range of 30–100 μm, the wear resistance (as assessed by linear wear) of ion-plasma coatings is higher than that of gas-flame coatings. This predetermines the fact that in the event of a catastrophic collision between the coatings and a blade, the geometry of the damage to the surface of the gas-flame coating will be greater than that of the ion-plasma coating. In the event of damage exceeding 75–100 μm in depth, both coatings become inoperable, since their wear characteristics are no longer maintained. This is indicated by a rapid decrease in their wear resistance under step loading. Moreover, the gas-flame coating is more prone to catastrophic failure than the ion-plasma coating. Full article

Mangrove ecosystems are recognized as highly efficient blue-carbon reservoirs, yet their monitoring requires scalable, transparent methods suitable for climate-finance and greenhouse-gas accounting applications. This study quantifies interannual carbon-stock dynamics and derives a carbon-market valuation indicator for Ecuador’s Churute Mangrove Ecological Reserve (2015–2021) using publicly available remote-sensing land-cover products. Annual activity data were derived from Copernicus Global Land Service LC100 (100 m, 2015–2019) and ESA WorldCover (10 m, 2020–2021), harmonized to a common reporting scheme, and combined with IPCC Tier 1 default coefficients for biomass and soil organic carbon in tropical wetlands. Total carbon stocks averaged 1.67 million t C across the period, remaining stable within the internally consistent LC100 phase (2015–2019), with trend statistics treated as descriptive given the short annual series, while a pronounced drop in 2020 primarily reflected methodological discontinuities between products rather than ecological change. Converted to CO₂e equivalents (mean 6.1 million t CO₂e), illustrative market values fluctuated between USD 18 and 123 million annually, driven predominantly by carbon-price variability. This remote-sensing-based, MRV-aligned approach provides a conservative baseline for protected-area blue-carbon accounting, highlighting the need for homogeneous high-resolution time series to distinguish real dynamics from classification artifacts in future assessments. Full article

The present numerical study simultaneously investigates the aerodynamic performance, shape optimization, and aeroacoustic characteristics of modified leading-edge wavy wings for the NACA 0020 airfoil. Unlike conventional passive flow-control approaches, the present study proposes a collaborative vortex–slot control strategy, where streamwise vortices induced by a wavy leading edge interact constructively with momentum injection from upper-surface slot channels. Flow field is analyzed at a Reynolds number of 290,000 and various angles of attack (AoA) utilizing Computational Fluid Dynamics (CFD). Three leading-edge wavy wing configurations, namely A3L11, A3L40 and A11L40, are examined and further modified by introducing streamwise slots near the leading edge on the upper surface of the wing. Three slot diameters (0.07c, 0.10c, and 0.13c) are examined at a constant draft angle of 7.5°, which represents the inclination of the slot relative to the wing surface. The numerical results are validated against experimental data available in the literature. The findings indicate that the A3L11 configuration with a 0.07c slot diameter, as well as the A11L40 configuration at high angles of attack, outperform the baseline wavy wing. This improvement is attributed to the slotting mechanism, which enhances surface suction and streamwise momentum, thereby improving boundary-layer behavior. An increase in aerodynamic efficiency, quantified by the lift-to-drag ratio, is observed at 20° AoA for all configurations. To further enhance performance, shape optimization is performed by optimizing the slot diameter and the distance between the chord line and the slot center using a Genetic Algorithm (GA), with the A11L40 configuration at 20° AoA identified as the optimal design. The optimized configuration yields an overall aerodynamic performance improvement of approximately 27.76% compared to the smooth wing, while broadband aeroacoustic source modeling indicates a relative reduction in predicted noise-source intensity relative to the baseline modified wing. The results are presented through combined quantitative metrics and qualitative flow analyses, demonstrating the potential applicability of the proposed optimization framework to low-Reynolds-number aerodynamic and aeroacoustic design problems, such as those encountered in small-scale air vehicles, bio-inspired wings, and noise-sensitive systems. Full article

Mitochondria are central regulators of cardiac homeostasis, integrating energy production, redox balance, calcium handling, and innate immune signaling. In cardiovascular disease (CVD), mitochondrial dysfunction acts as a unifying mechanism connecting oxidative stress, metabolic inflexibility, inflammation, and structural remodeling. Disturbances in mitochondrial quality control—encompassing fusion–fission dynamics, PINK1/Parkin- and receptor-mediated mitophagy, biogenesis, and proteostasis—compromise mitochondrial integrity and amplify cardiomyocyte injury. Excess reactive oxygen species, mitochondrial DNA release, and calcium overload further activate cGAS–STING, NLRP3 inflammasomes, and mPTP-driven cell death pathways, perpetuating maladaptive remodeling. Therapeutic strategies targeting mitochondrial dysfunction have rapidly expanded, ranging from mitochondria-targeted antioxidants (such as MitoQ and SS-31), nutraceuticals, metabolic modulators (SGLT2 inhibitors, metformin), and mitophagy or biogenesis activators to innovative approaches including mtDNA editing, nanocarrier-based delivery, and mitochondrial transplantation. These interventions aim to restore organelle structure, improve bioenergetics, and reestablish balanced quality control networks. This review integrates recent mechanistic insights with emerging translational evidence, outlining how mitochondria function as bioenergetic and inflammatory hubs in CVD. By synthesizing established and next-generation therapeutic strategies, it highlights the potential of precision mitochondrial medicine to reshape the future management of cardiovascular disease. Full article

Tuna peptides possess significant bioactivity but are limited by their persistent fishy odor. This study employed mild oxidation with medical-grade hydrogen peroxide (3% H₂O₂) to deodorize tuna peptides. The optimal parameters determined through single-factor and orthogonal experiments were 798 mmol/L H₂O₂, 35 °C, and 20 min. Under these conditions, the sensory score decreased markedly from 5 (very strong odor) to 2.48 (slight odor). Solid-phase microextraction and gas chromatography/mass spectrometry (SPME-GC/MS) analysis confirmed the complete removal of key odorants such as octanal and heptanal, along with a 44.8–54.7% reduction in other volatile compounds. Importantly, the treated peptides retained substantial antioxidant activity, with 2,2-azinobis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) and 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging rates of 91.5% and 78.3%, respectively. Successful incorporation of the deodorized peptides into a moisturizer demonstrated effective and lasting odor reduction. The proposed method offers an efficient, mild, and industrially viable strategy to expand the application of tuna peptides in functional cosmetics and foods. Full article

Biochar activation is critical for producing high-performance adsorbents; however, conventional activation methods are energy-intensive and difficult to control, particularly when air is used as an activating agent. This study investigates CO₂–air co-activation in a laboratory-scale fluidized bed reactor as an energy-efficient alternative. Experiments were conducted at 750–850 °C under varying gas flow rates with a constant CO₂/O₂ ratio. Optimal properties were achieved at 800 °C and 0.2–0.3 L/min CO₂, yielding a maximum BET surface area of 479 m²/g, a micropore contribution of 42%, and controlled carbon conversion (~25–35% yield). Aspen Plus equilibrium simulations also confirm that CO₂-only activation remains endothermic (heat duty up to +0.07 kW), air-only activation becomes strongly exothermic (down to −0.13 kW), while the CO₂–air mixture exhibits near-thermoneutral to mildly exothermic behavior (+0.13 to −0.10 kW), thereby reducing external energy demand potentially by approximately 60–70% compared with CO₂-only activation and significantly improving process stability. These results demonstrate that CO₂–air co-activation offers a practical route to produce high-quality activated biochar with controlled porosity and improved energy efficiency. Full article

Background/Objectives: Comprehensive Geriatric Assessment (CGA) is essential for maintaining quality of life (QOL) and independence in older adults. Still, its implementation is labor-intensive and difficult to sustain in aging societies such as Japan. Digital technologies may enable continuous, scalable CGA in daily living environments. This study aimed to develop and preliminarily evaluate a digital CGA (D-CGA) framework by integrating data from multiple monitoring devices, as a preparatory step toward Artificial Intelligence (AI)-supported personalized care planning. Methods: Four devices (Handy, Apple Watch, Withings Sleep, and Vieureka) were selected. Due to ethical constraints in Japan, a pilot study was conducted with graduate students. Participants underwent continuous monitoring for five weekdays. Common and device-specific measurement items were extracted, visualized, and compared across devices. Heart rate data were examined using correlation-based analyses. Baseline CGA was conducted before monitoring. Results: Distributional and temporal characteristics of physiological measures were explored separately for daytime and nocturnal periods. Continuous heart rate and respiratory rate data were successfully collected across monitoring days, demonstrating the feasibility of real-life data acquisition using the selected devices. Heart and respiratory rates showed distinct distributional patterns between daytime and nocturnal periods, supporting context-specific physiological characterization. Conclusions: This pilot study demonstrates the feasibility of integrating multi-device data for D-CGA and provides foundational reference data for future studies of older adults. The results support the potential of D-CGA to inform personalized care and guide subsequent large-scale and clinical investigations. Full article

Emerging mosquito-borne flaviviruses, such as Dengue virus (DENV) and Zika virus (ZIKV), pose major global public health threats due to their geographic expansion, climate change, and the absence of effective antiviral therapies. Antiviral development against these pathogens has primarily focused on two complementary strategies. On the one hand, the blocking of viral replication by directly inhibiting essential viral enzymes, and on the other, enhancing the host’s innate immune defenses via targeted activation of intracellular antiviral pathways. Among the viral proteins required for replication, the NS2B–NS3 protease complex is one of the most conserved and druggable targets, prompting extensive efforts to design both covalent and non-covalent inhibitors. Covalent inhibitors, such as boronic acids, aldehydes, trifluoromethyl ketones, phenoxymethylphenyl derivatives, and α-ketoamides, form irreversible or slowly reversible bonds with the catalytic serine residue (Ser 135), producing long-lasting and high-affinity suppression of protease activity. In parallel, several classes of non-covalent, particularly allosteric, inhibitors have emerged as promising alternatives with improved specificity and reduced off-target reactivity. A complementary antiviral strategy involves the use of agonists of key innate immune sensors such as TLRs, RIG-I, and the cGAS–STING axis, which mediate the release of interferons (IFNs). This review brings together current knowledge on these two mechanistically distinct yet convergent approaches, highlighting how both can ultimately restrict flavivirus replication. Future opportunities involving modified peptide scaffolds, advanced delivery systems, and drug-repurposing strategies are finally discussed for the development of next-generation therapeutics against DENV and ZIKV. Full article

This paper explores the intertwined relationship between food systems and climate change, emphasizing their role in achieving the global target of limiting warming to 1.5 °C above pre-industrial levels. Food systems contribute significantly to greenhouse gas emissions; approximately 30% of global CO₂ emanates from agricultural practices, livestock production, and export-oriented supply chains. Conversely, climate change disrupts food production via rising temperatures, sea-level rise, and water scarcity, particularly in vulnerable regions such as Namibia and other parts of the Southern Hemisphere. In contrast, the European Arctic faces unique opportunities and challenges. This paper highlights mitigation and adaptation strategies, including smart agriculture technologies and genetic crop engineering. Behavioural shifts toward plant-based diets and strengthening local food systems are identified as critical for reducing emissions and enhancing resilience. Furthermore, the value of Indigenous knowledge and traditional food systems, which promote biodiversity, minimize fossil fuel use, and offer climate-resilient crops, is highlighted. Institutional capacity and governance frameworks are pivotal for implementing these solutions. The authors advocate for co-production of knowledge between the Northern and Southern Hemispheres, ensuring equitable adaptation rather than one-way technology transfer. Ultimately, integrated strategies combining technological innovation, policy reform, and cultural resilience are essential to break the cycle between food systems and climate change, fostering global cooperation toward the 1.5 °C goal. Full article

In the process of using the freezing method to uncover coal from stone gates, the thermal evolution profiles of the coal body during the freezing process tend to be complex due to the presence of gas and moisture. To investigate the temperature response of coal containing gas under different freezing temperature conditions, a self-developed low-temperature freezing test system for coal containing water and gas was used to conduct freezing and cooling tests at different freezing temperatures (−5 °C to −30 °C). The temperature changes at various measuring points inside the coal over time were monitored in real time, and the temperature distribution, cooling law, and strain evolution process of the coal in the axial and radial directions were analyzed. The experimental results show that the cooling process of the center point of the coal can be divided into four stages: rapid cooling, extremely slow temperature drop, relatively slow cooling, and stable constant temperature. The time required to reach the stable constant temperature stage is inversely proportional to the freezing temperature, and corresponding prediction formulas have been established based on this. The standardized coal briquettes exhibit a gradient distribution characteristic of gradually increasing temperature from outside to inside in both axial and radial directions, with the radial temperature distribution being well matched by an exponential decay model. The strain of coal is affected by both thermal shrinkage and ice-induced expansion. The occurrence time of frost heave is positively correlated with freezing temperature, while the strain of frost heave is negatively correlated with freezing temperature. The axial frost heave effect is significantly stronger than the radial effect, but the radial frost heave occurs slightly earlier than the axial effect. This study reveals the thermal-mechanical coupling response mechanism of gas-containing coal during the low-temperature freezing process, and the research results can provide theoretical support for parameter optimization and engineering application of low-temperature freezing anti-outburst technology. Full article

Although Afghanistan’s contribution to global and regional greenhouse gas (GHG) emissions is minimal, it remains among the countries most vulnerable to the impacts of climate change. Rising temperatures and decreasing precipitation have significantly disrupted the country’s natural resources, including water supplies, agriculture, forests, rangelands, and ecosystems, threatening its agrarian economy and socio-economic stability. Simultaneously, Afghanistan has substantial untapped renewable energy potential, especially in hydropower, solar, wind, and biomass. This study analyzes historical (1970–2014) and projected (2015–2099) climate trends across Afghanistan by examining mean annual temperature and precipitation using the Mann–Kendall test and Sen’s Slope estimator. Results indicate a significant warming trend, with a 1.58 °C rise in temperature and a 36 mm decrease in annual precipitation over the past five decades. Future projections based on Shared Socioeconomic Pathways (SSPs) from the Coupled Model Intercomparison Project Phase 6 (CMIP6) suggest continued temperature increases, while precipitation trends vary geographically and over time, showing increases, decreases, or little change. The study also evaluates Afghanistan’s GHG emissions, which are negligible on regional and global scales. Despite its abundant renewable energy resources, the country still depends heavily on electricity imports from neighboring nations, leaving much of its domestic potential untapped. Harnessing these renewable resources can provide a practical path toward energy independence, zero-emission energy generation, and sustainable long-term development. This research emphasizes the urgent need for Afghanistan to strategically develop its renewable energy sector to boost climate resilience, enhance energy security, and promote sustainable economic growth. Full article

With the advancement of unmanned aerial vehicle (UAV) technology, its use in ecological monitoring and safety management of national parks has expanded significantly. However, object detection in complex scenes remains challenging due to environmental complexity, background interference, and occlusion. To address these issues, this paper proposes two improved YOLOv8-based models, YOLOv8-StarNet-CGA and SCS-YOLOv8, for detecting pine wilt disease-infected trees, under-construction farmhouses, and forest fires. In YOLOv8-StarNet-CGA, the StarNet module and Content-Guided Attention (CGA) are integrated into the backbone to enhance global feature extraction and focus on critical regions through dynamic weight adjustment. In SCS-YOLOv8, the original CIoU loss is also replaced with SIoU loss to optimize shape and orientation consistency, improving robustness. Experiments on UAV datasets covering diverse national park scenes demonstrate the effectiveness of the models. Results show that the improved models substantially outperform the original YOLOv8 in Precision, Recall, and mAP50. For pine wilt disease caused by the pine wood nematode Bursaphelenchus xylophilus, YOLOv8-StarNet-CGA achieves 8.6% higher Precision and 11.7% higher mAP50, facilitating early diagnosis and intervention of the disease. In under-construction farmhouse scenarios, Precision rises by 11% and mAP50 by 10.1%, lowering annual inspection labor by nearly 30% and improving oversight. For forest fires, SCS-YOLOv8 is more effective, with Precision improved by 7.2% and mAP50 by 6.3%. The improved detection model enables earlier identification of fire spots, thereby providing additional response time for emergency intervention, helping to mitigate fire spread and reduce the loss of forest resources. Both models also reduce GFLOPs and computational complexity, striking a balance between efficiency and accuracy, and showing strong potential for UAV deployment. Full article

Background/Objectives: We performed a systematic review of preclinical literature on the use of high-LET particle therapy, DDRi, and/or immunotherapy specifically in pMMR colorectal cancer. Methods: A systematic review of the literature published between 2014 and 2025 was conducted across major databases. Studies were included if they examined particle radiotherapy (e.g., proton, alpha, and carbon) or X-ray radiation either alone or in combination with DDRi and/or immune checkpoint inhibitors (ICIs) in pMMR colorectal cancer models. Results: In total, 131 studies met the inclusion criteria, including 70 preclinical studies. These studies consistently demonstrate that high-LET radiation amplifies immunogenic cell death, increases cGAS-STING pathway activation, and enhances tumor antigen presentation, thereby fostering greater immune infiltration and systemic antitumor responses. Concurrent irradiation with DDRi enhances persistent DNA damage and cytosolic DNA accumulation. In murine models, high-LET therapies show excellent local control, with manageable toxicity profiles. Combination regimens with ICIs exhibit improved local control and elicit systemic antitumor immune responses. Conclusions: High-LET particle radiation and/or the use of concurrent DDRi with ICI have significant preclinical evidence of immunostimulatory effects in pMMR rectal adenocarcinoma and increased response rates to immunotherapy. The clinical evidence will be reviewed in the companion manuscript. Full article

As an important type of power and domestic coal, long-flame coal plays a significant role in China’s energy structure. In this study, long-flame coal from Dongsheng, Inner Mongolia (DS) and its vitrinite-enriched fraction (DSV) prepared by organic solvent flotation separation method were selected as research objects. Simultaneous thermal analyzer (TGA), thermogravimetry-gas chromatography-mass spectrometry (TG-GC/MS), and Gray-King assay of coal were mainly employed to investigate their pyrolysis characteristics and differences in pyrolysis products. Results indicate that at the same final pyrolysis temperature, the CO₂ content in the pyrolysis gas of DS is higher than that of DSV, while CO, CH₄, and C_mH_n follow the order of DSV > DS. At 400−600 °C, pyrolysis tar mainly comprises monocyclic aromatic hydrocarbons (MAHs), polycyclic aromatic hydrocarbons (PAHs), aliphatic hydrocarbons, phenols and other oxygen heteroatom-containing organics (OHCs). Except for aliphatic hydrocarbons and OHCs, the contents of other components reach their maximum values at 500 °C, with peak area intensities of 3.192 × 10⁸, 5.841 × 10⁸, and 8.562 × 10⁸, respectively. In summary, when compared with DS, DSV exhibits more pronounced volatile release and higher reactivity. Full article