Next Article in Journal
Strategies for Using Polydopamine to Induce Biomineralization of Hydroxyapatite on Implant Materials for Bone Tissue Engineering
Previous Article in Journal
The Beneficial Effects of Morusin, an Isoprene Flavonoid Isolated from the Root Bark of Morus
Previous Article in Special Issue
Signal Exchange through Extracellular Vesicles in Neuromuscular Junction Establishment and Maintenance: From Physiology to Pathology
Review

Large Extracellular Vesicles—A New Frontier of Liquid Biopsy in Oncology

1
Department of Biomedical Sciences and Human Oncology, University of Bari ‘Aldo Moro’, 70121 Bari, Italy
2
National Cancer Center, Tumori Institute Giovanni Paolo II, 70121 Bari, Italy
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(18), 6543; https://doi.org/10.3390/ijms21186543
Received: 13 August 2020 / Revised: 2 September 2020 / Accepted: 4 September 2020 / Published: 7 September 2020
Extracellular Vesicles (EVs) are emerging as pivotal elements in cancer. Many studies have focused on the role of Small- (S)-EVs but in recent years Large-(L)-EVs have progressively gained increasing interest due to their peculiar content and functions. Tumor-derived L-EVs carry a lot of oncogenic proteins, nucleic acids and lipids to recipient cells and are involved in the reshaping of the tumor microenvironment as well as in the metabolic rewiring and the promotion of the pro-metastatic attitude of cancer cells. Several techniques have been developed for the isolation of L-EVs and commercial kits are also available for efficient and easy recovery of these vesicles. Also, the improvement in DNA sequencing and “omics sciences” profoundly changed the way to analyze and explore the molecular content of L-EVs, thus providing novel and potentially useful cancer biomarkers. Herein, we review the most recent findings concerning the role of L-EVs in cancer and discuss their possible use in oncology as “liquid biopsy” tools as compared to the other classes of EVs. View Full-Text
Keywords: large extracellular vesicles; microvesicles; oncosomes; exosomes; cancer large extracellular vesicles; microvesicles; oncosomes; exosomes; cancer
Show Figures

Figure 1

MDPI and ACS Style

Pezzicoli, G.; Tucci, M.; Lovero, D.; Silvestris, F.; Porta, C.; Mannavola, F. Large Extracellular Vesicles—A New Frontier of Liquid Biopsy in Oncology. Int. J. Mol. Sci. 2020, 21, 6543. https://doi.org/10.3390/ijms21186543

AMA Style

Pezzicoli G, Tucci M, Lovero D, Silvestris F, Porta C, Mannavola F. Large Extracellular Vesicles—A New Frontier of Liquid Biopsy in Oncology. International Journal of Molecular Sciences. 2020; 21(18):6543. https://doi.org/10.3390/ijms21186543

Chicago/Turabian Style

Pezzicoli, Gaetano, Marco Tucci, Domenica Lovero, Franco Silvestris, Camillo Porta, and Francesco Mannavola. 2020. "Large Extracellular Vesicles—A New Frontier of Liquid Biopsy in Oncology" International Journal of Molecular Sciences 21, no. 18: 6543. https://doi.org/10.3390/ijms21186543

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop