Next Article in Journal
Tumors Resistant to Checkpoint Inhibitors Can Become Sensitive after Treatment with Vascular Disrupting Agents
Previous Article in Journal
Emerging Roles of Matricellular Proteins in Systemic Sclerosis
Previous Article in Special Issue
Multifaceted Role of PRDM Proteins in Human Cancer
Review

NRF2, a Transcription Factor for Stress Response and Beyond

by 1,*,†, 2,† and 3,*
1
Laboratory of Gene Regulation and Signal Transduction, Departments of Pharmacology, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
2
Department of Gynecology and Obstetrics, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China
3
Medical Research Center, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2020, 21(13), 4777; https://doi.org/10.3390/ijms21134777
Received: 16 June 2020 / Revised: 1 July 2020 / Accepted: 3 July 2020 / Published: 6 July 2020
(This article belongs to the Special Issue Zinc-Finger Proteins in Health and Disease: Focus on PRDMs)
Nuclear factor erythroid 2-related factor 2 (NRF2) is a transcription factor that regulates the cellular defense against toxic and oxidative insults through the expression of genes involved in oxidative stress response and drug detoxification. NRF2 activation renders cells resistant to chemical carcinogens and inflammatory challenges. In addition to antioxidant responses, NRF2 is involved in many other cellular processes, including metabolism and inflammation, and its functions are beyond the originally envisioned. NRF2 activity is tightly regulated through a complex transcriptional and post-translational network that enables it to orchestrate the cell’s response and adaptation to various pathological stressors for the homeostasis maintenance. Elevated or decreased NRF2 activity by pharmacological and genetic manipulations of NRF2 activation is associated with many metabolism- or inflammation-related diseases. Emerging evidence shows that NRF2 lies at the center of a complex regulatory network and establishes NRF2 as a truly pleiotropic transcription factor. Here we summarize the complex regulatory network of NRF2 activity and its roles in metabolic reprogramming, unfolded protein response, proteostasis, autophagy, mitochondrial biogenesis, inflammation, and immunity. View Full-Text
Keywords: NRF2; metabolism; UPR; oxidative stress; inflammation; autophagy; proteostasis; transcription factor NRF2; metabolism; UPR; oxidative stress; inflammation; autophagy; proteostasis; transcription factor
Show Figures

Figure 1

MDPI and ACS Style

He, F.; Ru, X.; Wen, T. NRF2, a Transcription Factor for Stress Response and Beyond. Int. J. Mol. Sci. 2020, 21, 4777. https://doi.org/10.3390/ijms21134777

AMA Style

He F, Ru X, Wen T. NRF2, a Transcription Factor for Stress Response and Beyond. International Journal of Molecular Sciences. 2020; 21(13):4777. https://doi.org/10.3390/ijms21134777

Chicago/Turabian Style

He, Feng, Xiaoli Ru, and Tao Wen. 2020. "NRF2, a Transcription Factor for Stress Response and Beyond" International Journal of Molecular Sciences 21, no. 13: 4777. https://doi.org/10.3390/ijms21134777

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop