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Review

Capsaicin-Sensitive Sensory Nerves and the TRPV1 Ion Channel in Cardiac Physiology and Pathologies

1
Cardiovascular Research Group, Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Szeged, H-6720 Szeged, Hungary
2
Department of Physiology, Faculty of Medicine, University of Szeged, H-6720 Szeged, Hungary
3
Department of Pharmacology and Pharmacotherapy, Semmelweis University, H-1089 Budapest, Hungary
4
Department of Pharmacology and Pharmacotherapy, Medical School & Molecular Pharmacology Research Group, Centre for Neuroscience, János Szentágothai Research Centre, University of Pécs, H-7624 Pécs, Hungary
5
PharmInVivo Ltd., H-7629 Pécs, Hungary
6
Pharmahungary Group, H-6722 Szeged, Hungary
*
Author to whom correspondence should be addressed.
Authors equally contributed to the work.
Int. J. Mol. Sci. 2020, 21(12), 4472; https://doi.org/10.3390/ijms21124472
Received: 5 June 2020 / Accepted: 20 June 2020 / Published: 23 June 2020
(This article belongs to the Special Issue Capsaicin and TRPV1 in the Study of Pain and Organ Pathologies)
Cardiovascular diseases, including coronary artery disease, ischemic heart diseases such as acute myocardial infarction and postischemic heart failure, heart failure of other etiologies, and cardiac arrhythmias, belong to the leading causes of death. Activation of capsaicin-sensitive sensory nerves by the transient receptor potential vanilloid 1 (TRPV1) capsaicin receptor and other receptors, as well as neuropeptide mediators released from them upon stimulation, play important physiological regulatory roles. Capsaicin-sensitive sensory nerves also contribute to the development and progression of some cardiac diseases, as well as to mechanisms of endogenous stress adaptation leading to cardioprotection. In this review, we summarize the role of capsaicin-sensitive afferents and the TRPV1 ion channel in physiological and pathophysiological functions of the heart based mainly on experimental results and show their diagnostic or therapeutic potentials. Although the actions of several other channels or receptors expressed on cardiac sensory afferents and the effects of TRPV1 channel activation on different non-neural cell types in the heart are not precisely known, most data suggest that stimulation of the TRPV1-expressing sensory nerves or stimulation/overexpression of TRPV1 channels have beneficial effects in cardiac diseases. View Full-Text
Keywords: acute myocardial infarction; arrhythmia; atherosclerosis; capsaicin; cardioprotection; ischemic heart disease; heart failure; transient receptor potential vanilloid type 1 (TRPV1) receptor acute myocardial infarction; arrhythmia; atherosclerosis; capsaicin; cardioprotection; ischemic heart disease; heart failure; transient receptor potential vanilloid type 1 (TRPV1) receptor
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MDPI and ACS Style

Szabados, T.; Gömöri, K.; Pálvölgyi, L.; Görbe, A.; Baczkó, I.; Helyes, Z.; Jancsó, G.; Ferdinandy, P.; Bencsik, P. Capsaicin-Sensitive Sensory Nerves and the TRPV1 Ion Channel in Cardiac Physiology and Pathologies. Int. J. Mol. Sci. 2020, 21, 4472. https://doi.org/10.3390/ijms21124472

AMA Style

Szabados T, Gömöri K, Pálvölgyi L, Görbe A, Baczkó I, Helyes Z, Jancsó G, Ferdinandy P, Bencsik P. Capsaicin-Sensitive Sensory Nerves and the TRPV1 Ion Channel in Cardiac Physiology and Pathologies. International Journal of Molecular Sciences. 2020; 21(12):4472. https://doi.org/10.3390/ijms21124472

Chicago/Turabian Style

Szabados, Tamara, Kamilla Gömöri, Laura Pálvölgyi, Anikó Görbe, István Baczkó, Zsuzsanna Helyes, Gábor Jancsó, Péter Ferdinandy, and Péter Bencsik. 2020. "Capsaicin-Sensitive Sensory Nerves and the TRPV1 Ion Channel in Cardiac Physiology and Pathologies" International Journal of Molecular Sciences 21, no. 12: 4472. https://doi.org/10.3390/ijms21124472

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