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Article

Modified Carboxyl-Terminated PAMAM Dendrimers as Great Cytocompatible Nano-Based Drug Delivery System

1
Institute of Chemistry and Materials, 17 Hoang Sam, Cau Giay, Hanoi 100000, Vietnam
2
NTT Hi-Tech Institute, Nguyen Tat Thanh University, Ho Chi Minh City 700000, Vietnam
3
Center of Excellence for Functional Polymers and NanoEngineering, Nguyen Tat Thanh University, Ho Chi Minh City 700000, Vietnam
4
Institute of Applied Materials Science, Vietnam Academy of Science and Technology, Ho Chi Minh City 700000, Vietnam
5
Graduate University of Science and Technology, Vietnam Academy of Science and Technology, Hanoi 100000, Vietnam
6
Biomaterials and Nanotechnology Research Group, Faculty of Applied Sciences, Ton Duc Thang University, Ho Chi Minh City 700000, Vietnam
*
Author to whom correspondence should be addressed.
This author contributed equally to this work.
Int. J. Mol. Sci. 2019, 20(8), 2016; https://doi.org/10.3390/ijms20082016
Received: 20 March 2019 / Revised: 10 April 2019 / Accepted: 11 April 2019 / Published: 24 April 2019
(This article belongs to the Special Issue Nanotechnology in Cancer Treatment)
Polyamidoamine (PAMAM) dendrimers are extensively researched as potential drug delivery system thanks to their desirable features such as controlled and stable structures, and ease of functionalization onto their surface active groups. However, there have been concerns about the toxicity of full generation dendrimers and risks of premature clearance from circulation, along with other physical drawbacks presented in previous formulations, including large particle sizes and low drug loading efficiency. In our study, carboxyl-terminated PAMAM dendrimer G3.5 was grafted with poly (ethylene glycol) methyl ether (mPEG) to be employed as a nano-based drug delivery system with great cytocompatibility for the delivery of carboplatin (CPT), a widely prescribed anticancer drug with strong side effects so that the drug will be effectively entrapped and not exhibit uncontrolled outflow from the open structure of unmodified PAMAM G3.5. The particles formed were spherical in shape and had the optimal size range (around 36 nm) that accommodates high drug entrapment efficiency. Surface charge was also determined to be almost neutral and the system was cytocompatible. In vitro release patterns over 24 h showed a prolonged CPT release compared to free drug, which correlated to the cytotoxicity assay on malignant cell lines showing the lack of anticancer effect of CPT/mPEG-G3.5 compared with CPT. View Full-Text
Keywords: half generation polyamidoamine (PAMAM) dendrimer; carboplatin; PEGylation; drug delivery system; cancer treatment half generation polyamidoamine (PAMAM) dendrimer; carboplatin; PEGylation; drug delivery system; cancer treatment
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MDPI and ACS Style

Vu, M.T.; Bach, L.G.; Nguyen, D.C.; Ho, M.N.; Nguyen, N.H.; Tran, N.Q.; Nguyen, D.H.; Nguyen, C.K.; Hoang Thi, T.T. Modified Carboxyl-Terminated PAMAM Dendrimers as Great Cytocompatible Nano-Based Drug Delivery System. Int. J. Mol. Sci. 2019, 20, 2016. https://doi.org/10.3390/ijms20082016

AMA Style

Vu MT, Bach LG, Nguyen DC, Ho MN, Nguyen NH, Tran NQ, Nguyen DH, Nguyen CK, Hoang Thi TT. Modified Carboxyl-Terminated PAMAM Dendrimers as Great Cytocompatible Nano-Based Drug Delivery System. International Journal of Molecular Sciences. 2019; 20(8):2016. https://doi.org/10.3390/ijms20082016

Chicago/Turabian Style

Vu, Minh T., Long G. Bach, Duy C. Nguyen, Minh N. Ho, Ngoc H. Nguyen, Ngoc Q. Tran, Dai H. Nguyen, Cuu K. Nguyen, and Thai T. Hoang Thi 2019. "Modified Carboxyl-Terminated PAMAM Dendrimers as Great Cytocompatible Nano-Based Drug Delivery System" International Journal of Molecular Sciences 20, no. 8: 2016. https://doi.org/10.3390/ijms20082016

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