High Body Mass Index is Associated with Elevated Blood Levels of Progerin mRNA
AbstractObesity is a well-described risk factor resulting in premature aging of the cardiovascular system ultimately limiting longevity. Premature cardiac death and aging is the hallmark of Hutchinson–Gilford syndrome (HGPS), a disease caused by defined mutations in the lamin A gene leading to a shortened prelamin A protein known as progerin. Since small amounts of progerin are expressed in healthy individuals we aimed to investigate the association of Body-Mass-Index (BMI) with respect to expression of progerin mRNA in blood samples of patient with known cardiovascular disease. In this cross-sectional retrospective analysis, 111 patients were consecutively included of which 46 were normal (BMI < 25 kg/m2) and 65 overweight (BMI ≥ 25.0 kg/m2). Blood samples were analyzed for quantitative expression of progerin mRNA. Progerin as well as high-sensitive C-Reactive Protein (hs-CRP) levels were significantly upregulated in the overweight group. Linear regression analyses showed a significant positive correlation of BMI and progerin mRNA (n = 111; r = 0.265, p = 0.005), as well as for hs-CRP (n = 110; r = 0.300, p = 0.001) and for Hb1Ac (n = 110; r = 0.336, p = 0.0003). Our data suggest that BMI strongly correlates with progerin mRNA expression and inflammation. Progerin might contribute to well described accelerated biologic aging in obese individuals. View Full-Text
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Messner, M.; Ghadge, S.K.; Schuetz, T.; Seiringer, H.; Pölzl, G.; Zaruba, M.-M. High Body Mass Index is Associated with Elevated Blood Levels of Progerin mRNA. Int. J. Mol. Sci. 2019, 20, 1976.
Messner M, Ghadge SK, Schuetz T, Seiringer H, Pölzl G, Zaruba M-M. High Body Mass Index is Associated with Elevated Blood Levels of Progerin mRNA. International Journal of Molecular Sciences. 2019; 20(8):1976.Chicago/Turabian Style
Messner, Moritz; Ghadge, Santhosh K.; Schuetz, Thomas; Seiringer, Herbert; Pölzl, Gerhard; Zaruba, Marc-Michael. 2019. "High Body Mass Index is Associated with Elevated Blood Levels of Progerin mRNA." Int. J. Mol. Sci. 20, no. 8: 1976.
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