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High Body Mass Index is Associated with Elevated Blood Levels of Progerin mRNA

Department of Internal Medicine III, Cardiology and Angiology, Medical University Innsbruck, 6020 Innsbruck, Austria
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Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2019, 20(8), 1976; https://doi.org/10.3390/ijms20081976
Received: 12 February 2019 / Revised: 6 April 2019 / Accepted: 21 April 2019 / Published: 23 April 2019
(This article belongs to the Special Issue Mechanism of Longevity)
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Abstract

Obesity is a well-described risk factor resulting in premature aging of the cardiovascular system ultimately limiting longevity. Premature cardiac death and aging is the hallmark of Hutchinson–Gilford syndrome (HGPS), a disease caused by defined mutations in the lamin A gene leading to a shortened prelamin A protein known as progerin. Since small amounts of progerin are expressed in healthy individuals we aimed to investigate the association of Body-Mass-Index (BMI) with respect to expression of progerin mRNA in blood samples of patient with known cardiovascular disease. In this cross-sectional retrospective analysis, 111 patients were consecutively included of which 46 were normal (BMI < 25 kg/m2) and 65 overweight (BMI ≥ 25.0 kg/m2). Blood samples were analyzed for quantitative expression of progerin mRNA. Progerin as well as high-sensitive C-Reactive Protein (hs-CRP) levels were significantly upregulated in the overweight group. Linear regression analyses showed a significant positive correlation of BMI and progerin mRNA (n = 111; r = 0.265, p = 0.005), as well as for hs-CRP (n = 110; r = 0.300, p = 0.001) and for Hb1Ac (n = 110; r = 0.336, p = 0.0003). Our data suggest that BMI strongly correlates with progerin mRNA expression and inflammation. Progerin might contribute to well described accelerated biologic aging in obese individuals. View Full-Text
Keywords: aging; obesity; BMI; inflammation; lamin A/C; progerin; longevity aging; obesity; BMI; inflammation; lamin A/C; progerin; longevity
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Messner, M.; Ghadge, S.K.; Schuetz, T.; Seiringer, H.; Pölzl, G.; Zaruba, M.-M. High Body Mass Index is Associated with Elevated Blood Levels of Progerin mRNA. Int. J. Mol. Sci. 2019, 20, 1976.

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