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Non-Coding RNAs as New Therapeutic Targets in the Context of Renal Fibrosis

1
EA 4483-IMPECS-IMPact of Environmental ChemicalS on Human Health, Univ. Lille, 59045 Lille CEDEX, France
2
Département de la Recherche en Santé, CHU Lille, 59037 Lille, France
3
Service de Néphrologie, CHU Lille, 59037 Lille, France
4
Service de Toxicologie et Génopathies, CHU Lille, 59037 Lille, France
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(8), 1977; https://doi.org/10.3390/ijms20081977
Received: 28 March 2019 / Revised: 19 April 2019 / Accepted: 20 April 2019 / Published: 23 April 2019
(This article belongs to the Special Issue Kidney Inflammation, Injury and Regeneration)
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Abstract

Fibrosis, or tissue scarring, is defined as the excessive, persistent and destructive accumulation of extracellular matrix components in response to chronic tissue injury. Renal fibrosis represents the final stage of most chronic kidney diseases and contributes to the progressive and irreversible decline in kidney function. Limited therapeutic options are available and the molecular mechanisms governing the renal fibrosis process are complex and remain poorly understood. Recently, the role of non-coding RNAs, and in particular microRNAs (miRNAs), has been described in kidney fibrosis. Seminal studies have highlighted their potential importance as new therapeutic targets and innovative diagnostic and/or prognostic biomarkers. This review will summarize recent scientific advances and will discuss potential clinical applications as well as future research directions. View Full-Text
Keywords: non-coding RNAs; microRNAs; long non-coding RNAs; renal fibrosis; biomarkers; therapeutics targets non-coding RNAs; microRNAs; long non-coding RNAs; renal fibrosis; biomarkers; therapeutics targets
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Van der Hauwaert, C.; Glowacki, F.; Pottier, N.; Cauffiez, C. Non-Coding RNAs as New Therapeutic Targets in the Context of Renal Fibrosis. Int. J. Mol. Sci. 2019, 20, 1977.

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