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Int. J. Mol. Sci. 2019, 20(8), 1850; https://doi.org/10.3390/ijms20081850

Dietary Macronutrient Management to Treat Mitochondrial Dysfunction in Parkinson’s Disease

1
School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, Australia
2
School of Medical Sciences, University of New South Wales, Sydney, NSW 2052, Australia
*
Author to whom correspondence should be addressed.
Received: 27 February 2019 / Revised: 26 March 2019 / Accepted: 7 April 2019 / Published: 15 April 2019
(This article belongs to the Special Issue Mitochondrial Dysfunction and Oxidative Damage)
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Abstract

Mitochondrial dysfunction has been demonstrated to play an important role in the pathogenesis of Parkinson’s disease (PD). The products of several PD-associated genes, including alpha-synuclein, parkin, pink1, protein deglycase DJ-1, and leucine rich repeat kinase 2, have important roles in mitochondrial biology. Thus, modifying mitochondrial function could be a potential therapeutic strategy for PD. Dietary management can alter mitochondrial function as shifts in dietary macronutrients and their ratios in food can alter mitochondrial energy metabolism, morphology and dynamics. Our studies have established that a low protein to carbohydrate (P:C) ratio can increase lifespan, motor ability and mitochondrial function in a parkin mutant Drosophila model of PD. In this review, we describe mitochondrial dysfunction in PD patients and models, and dietary macronutrient management strategies to reverse it. We focus on the effects of protein, carbohydrate, fatty acids, and their dietary ratios. In addition, we propose potential mechanisms that can improve mitochondrial function and thus reverse or delay the onset of PD. View Full-Text
Keywords: diet; macronutrients; mitochondria; oxidative stress diet; macronutrients; mitochondria; oxidative stress
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Bajracharya, R.; Youngson, N.A.; Ballard, J.W.O. Dietary Macronutrient Management to Treat Mitochondrial Dysfunction in Parkinson’s Disease. Int. J. Mol. Sci. 2019, 20, 1850.

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