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Open AccessArticle

The Influence of Trehalose on Atherosclerosis and Hepatic Steatosis in Apolipoprotein E Knockout Mice

1
Chair of Pharmacology, Jagiellonian University Medical College, 31-531 Krakow, Poland
2
Department of Histology, Jagiellonian University Medical College, 33-332 Krakow, Poland
3
Chair of Pathomorphology, Jagiellonian University Medical College, 31-531 Krakow, Poland
*
Author to whom correspondence should be addressed.
Passed away.
Int. J. Mol. Sci. 2019, 20(7), 1552; https://doi.org/10.3390/ijms20071552
Received: 13 February 2019 / Revised: 11 March 2019 / Accepted: 24 March 2019 / Published: 28 March 2019
(This article belongs to the Section Molecular Pharmacology)
Atherosclerosis and nonalcoholic fatty liver disease (NAFLD) are frequent causes of death in the Western countries. Recently, it has been shown that autophagy dysfunction plays an important role in the pathogenesis of both atherosclerosis and NAFLD; thus, activators of autophagy might be useful for novel therapeutic interventions. Trehalose—a naturally occuring disaccharide present in plants, bacteria, fungi, insects, and certain types of shrimps—is a known inducer of autophagy. However, according to the literature, its anti-atherosclerotic and anti-steatotic potential seem to depend on the experimental setting. The aim of our study was to comprehensively describe the influence of a prolonged treatment with orally administered trehalose on the development of atherosclerotic lesions and hepatic steatosis in apolipoprotein E knockout (apoE−/−) mice in an experimental set up reflecting both moderate and severe proatherogenic conditions: male apoE−/− mice on a chow diet (CD) and female apoE−/− mice fed with a high-fat diet (HFD). We found that exogenous trehalose inhibited atherosclerosis and attenuated hepatic steatosis in apoE−/− mice. Such effects of trehalose were not associated with changes of plasma cholesterol, low-density lipoproteins (LDL), or high-density lipoproteins (HDL). Moreover, the anti-steatotic action of trehalose in the liver was associated with the induction of autophagy. The exact molecular mechanisms of both the anti-atherosclerotic action of trehalose and its inhibitory effect on liver steatosis require further clarification. View Full-Text
Keywords: atherosclerosis; fatty liver; trehalose; autophagy; apoE-knockout mice atherosclerosis; fatty liver; trehalose; autophagy; apoE-knockout mice
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Stachowicz, A.; Wiśniewska, A.; Kuś, K.; Kiepura, A.; Gębska, A.; Gajda, M.; Białas, M.; Totoń-Żurańska, J.; Stachyra, K.; Suski, M.; Jawień, J.; Korbut, R.; Olszanecki, R. The Influence of Trehalose on Atherosclerosis and Hepatic Steatosis in Apolipoprotein E Knockout Mice. Int. J. Mol. Sci. 2019, 20, 1552.

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