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Review

The Impact of Lactoferrin on the Growth of Intestinal Inhabitant Bacteria

1
Departamento de Sistemas Biológicos, Universidad Autónoma Metropolitana, Unidad Xochimilco (UAM-Xochimilco), Calzada del Hueso No. 1100, CdMx 04960, Mexico
2
Departamento de Biología Celular, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (CINVESTAV-IPN), Avenida IPN No. 2508, CdMx 07360, Mexico
3
Departamento de Inmunología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México (IIB-UNAM), Ciudad Universitaria, CdMx 70228, Mexico
4
Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional (ESM-IPN), Plan de San Luis y Díaz Mirón s/n, CdMx 11340, Mexico
*
Author to whom correspondence should be addressed.
Deceased.
Int. J. Mol. Sci. 2019, 20(19), 4707; https://doi.org/10.3390/ijms20194707
Received: 10 August 2019 / Revised: 16 September 2019 / Accepted: 20 September 2019 / Published: 23 September 2019
(This article belongs to the Section Molecular Immunology)
Lactoferrin (Lf) is an iron-binding milk glycoprotein that promotes the growth of selected probiotic strains. The effect of Lf on the growth and diversification of intestinal microbiota may have an impact on several issues, including (i) strengthening the permeability of the epithelial cell monolayer, (ii) favoring the microbial antagonism that discourages the colonization and proliferation of enteric pathogens, (iii) enhancing the growth and maturation of cell-monolayer components and gut nerve fibers, and (iv) providing signals to balance the anti- and pro-inflammatory responses resulting in gut homeostasis. Given the beneficial role of probiotics, this contribution aims to review the current properties of bovine and human Lf and their derivatives in in vitro probiotic growth and Lf interplay with microbiota described in the piglet model. By using Lf as a component in pharmacological products, we may enable novel strategies that promote probiotic growth while conferring antimicrobial activity against multidrug-resistant microorganisms that cause life-threatening diseases, especially in neonates. View Full-Text
Keywords: lactoferrin; lactoferricin; milk; lactobacilli; bifidobacteria; immunomodulation; intestinal homeostasis lactoferrin; lactoferricin; milk; lactobacilli; bifidobacteria; immunomodulation; intestinal homeostasis
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MDPI and ACS Style

Vega-Bautista, A.; de la Garza, M.; Carrero, J.C.; Campos-Rodríguez, R.; Godínez-Victoria, M.; Drago-Serrano, M.E. The Impact of Lactoferrin on the Growth of Intestinal Inhabitant Bacteria. Int. J. Mol. Sci. 2019, 20, 4707. https://doi.org/10.3390/ijms20194707

AMA Style

Vega-Bautista A, de la Garza M, Carrero JC, Campos-Rodríguez R, Godínez-Victoria M, Drago-Serrano ME. The Impact of Lactoferrin on the Growth of Intestinal Inhabitant Bacteria. International Journal of Molecular Sciences. 2019; 20(19):4707. https://doi.org/10.3390/ijms20194707

Chicago/Turabian Style

Vega-Bautista, Alan, Mireya de la Garza, Julio César Carrero, Rafael Campos-Rodríguez, Marycarmen Godínez-Victoria, and Maria Elisa Drago-Serrano. 2019. "The Impact of Lactoferrin on the Growth of Intestinal Inhabitant Bacteria" International Journal of Molecular Sciences 20, no. 19: 4707. https://doi.org/10.3390/ijms20194707

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