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Int. J. Mol. Sci. 2018, 19(9), 2608; https://doi.org/10.3390/ijms19092608

Effects of Iron Overload and Oxidative Damage on the Musculoskeletal System in the Space Environment: Data from Spaceflights and Ground-Based Simulation Models

1
School of Life Sciences, Northwestern Polytechnical University, Xi’an 710072, China
2
Key Laboratory for Space Bioscience and Biotechnology, Institute of Special Environment Biophysics, Northwestern Polytechnical University, Xi’an 710072, China
3
Research & Development Institute in Shenzhen, Northwestern Polytechnical University, Shenzhen 518057, China
*
Author to whom correspondence should be addressed.
Received: 15 August 2018 / Revised: 29 August 2018 / Accepted: 1 September 2018 / Published: 3 September 2018
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Abstract

The space environment chiefly includes microgravity and radiation, which seriously threatens the health of astronauts. Bone loss and muscle atrophy are the two most significant changes in mammals after long-term residency in space. In this review, we summarized current understanding of the effects of microgravity and radiation on the musculoskeletal system and discussed the corresponding mechanisms that are related to iron overload and oxidative damage. Furthermore, we enumerated some countermeasures that have a therapeutic potential for bone loss and muscle atrophy through using iron chelators and antioxidants. Future studies for better understanding the mechanism of iron and redox homeostasis imbalance induced by the space environment and developing the countermeasures against iron overload and oxidative damage consequently may facilitate human to travel more safely in space. View Full-Text
Keywords: iron overload; oxidative damage; microgravity; radiation; countermeasures iron overload; oxidative damage; microgravity; radiation; countermeasures
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Yang, J.; Zhang, G.; Dong, D.; Shang, P. Effects of Iron Overload and Oxidative Damage on the Musculoskeletal System in the Space Environment: Data from Spaceflights and Ground-Based Simulation Models. Int. J. Mol. Sci. 2018, 19, 2608.

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