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Int. J. Mol. Sci. 2018, 19(4), 1145; https://doi.org/10.3390/ijms19041145

CD147 Promotes CXCL1 Expression and Modulates Liver Fibrogenesis

1
Department of Cell Biology, National Translational Science Center for Molecular Medicine, State Key Laboratory of Cancer Biology, Fourth Military Medical University, Xi’an 710032, China
2
Department of Physiology, Basic Medical College, Shaanxi University of Chinese Medicine, Xianyang 712046, China
3
Clinical Laboratory, No. 457 Hospital of PLA, Wuhan 430000, China
*
Author to whom correspondence should be addressed.
Received: 27 January 2018 / Revised: 18 March 2018 / Accepted: 3 April 2018 / Published: 10 April 2018
(This article belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
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Abstract

Activated hepatic stellate cells (HSCs) release pro-inflammatory and pro-fibrogenic factors. CXC chemokine-ligand-1 (CXCL1) is expressed on HSCs. We previously found that the CD147 is overexpressed in activated HSCs. In this study, we showed an important role of CD147 in promoting liver fibrosis by activating HSCs and upregulating expression of chemokines. Specifically, we found that CD147 specific deletion in HSCs mice alleviated CCl4-induced liver fibrosis and inhibited HSCs activation. Overexpression of CD147 upregulated the secretion of CXCL1. Meanwhile, CXCL1 promoted HSCs activation through autocrine. Treating with PI3K/AKT inhibitor could effectively suppress CD147-induced CXCL1 expression. Taken together, these findings suggest that CD147 regulates CXCL1 release in HSCs by PI3K/AKT signaling. Inhibition of CD147 attenuates CCl4-induced liver fibrosis and inflammation. Therefore, administration of targeting CD147 could be a promising therapeutic strategy in liver fibrosis. View Full-Text
Keywords: CD147; CXCL1; hepatic stellate cells; fibrosis CD147; CXCL1; hepatic stellate cells; fibrosis
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Shi, W.-P.; Ju, D.; Li, H.; Yuan, L.; Cui, J.; Luo, D.; Chen, Z.-N.; Bian, H. CD147 Promotes CXCL1 Expression and Modulates Liver Fibrogenesis. Int. J. Mol. Sci. 2018, 19, 1145.

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