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Article

How Tyramine β-Hydroxylase Controls the Production of Octopamine, Modulating the Mobility of Beetles

by 1,2, 1,2, 1,2, 1,2, 1,2, 1,2, 1,2,3 and 1,2,*
1
Key Laboratory of Entomology and Pest Control Engineering, College of Plant Protection, Southwest University, Chongqing 400715, China
2
Academy of Agricultural Sciences, Southwest University, Chongqing 400715, China
3
Department of Crop Protection, Ghent University, 9000 Ghent, Belgium
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2018, 19(3), 846; https://doi.org/10.3390/ijms19030846
Received: 11 February 2018 / Revised: 4 March 2018 / Accepted: 9 March 2018 / Published: 14 March 2018
(This article belongs to the Section Biochemistry)
Biogenic amines perform many kinds of important physiological functions in the central nervous system (CNS) of insects, acting as neuromodulators, neurotransmitters, and neurohormones. The five most abundant types of biogenic amines in invertebrates are dopamine, histamine, serotonin, tyramine, and octopamine (OA). However, in beetles, an important group of model and pest insects, the role of tyramine β-hydroxylase (TβH) in the OA biosynthesis pathway and the regulation of behavior remains unknown so far. We therefore investigated the molecular characterization and spatiotemporal expression profiles of TβH in red flour beetles (Triboliun castaneum). Most importantly, we detected the production of OA and measured the crawling speed of beetles after dsTcTβH injection. We concluded that TcTβH controls the biosynthesis amount of OA in the CNS, and this in turn modulates the mobility of the beetles. Our new results provided basic information about the key genes in the OA biosynthesis pathway of the beetles, and expanded our knowledge on the physiological functions of OA in insects. View Full-Text
Keywords: Tribolium castaneum; octopamine; tyramine-β-hydroxylase; mobility Tribolium castaneum; octopamine; tyramine-β-hydroxylase; mobility
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MDPI and ACS Style

Xu, L.; Jiang, H.-B.; Chen, X.-F.; Xiong, Y.; Lu, X.-P.; Pei, Y.-X.; Smagghe, G.; Wang, J.-J. How Tyramine β-Hydroxylase Controls the Production of Octopamine, Modulating the Mobility of Beetles. Int. J. Mol. Sci. 2018, 19, 846. https://doi.org/10.3390/ijms19030846

AMA Style

Xu L, Jiang H-B, Chen X-F, Xiong Y, Lu X-P, Pei Y-X, Smagghe G, Wang J-J. How Tyramine β-Hydroxylase Controls the Production of Octopamine, Modulating the Mobility of Beetles. International Journal of Molecular Sciences. 2018; 19(3):846. https://doi.org/10.3390/ijms19030846

Chicago/Turabian Style

Xu, Li, Hong-Bo Jiang, Xiao-Feng Chen, Ying Xiong, Xue-Ping Lu, Yu-Xia Pei, Guy Smagghe, and Jin-Jun Wang. 2018. "How Tyramine β-Hydroxylase Controls the Production of Octopamine, Modulating the Mobility of Beetles" International Journal of Molecular Sciences 19, no. 3: 846. https://doi.org/10.3390/ijms19030846

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