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Int. J. Mol. Sci. 2017, 18(10), 2153; https://doi.org/10.3390/ijms18102153

Redox Signaling and Its Impact on Skeletal and Vascular Responses to Spaceflight

1
Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA 94035, USA
2
KBRWyle, Moffett Field, CA 94035, USA
*
Author to whom correspondence should be addressed.
Received: 2 September 2017 / Revised: 30 September 2017 / Accepted: 10 October 2017 / Published: 16 October 2017
(This article belongs to the Special Issue Oxidative Stress and Space Biology: An Organ-Based Approach)
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Abstract

Spaceflight entails exposure to numerous environmental challenges with the potential to contribute to both musculoskeletal and vascular dysfunction. The purpose of this review is to describe current understanding of microgravity and radiation impacts on the mammalian skeleton and associated vasculature at the level of the whole organism. Recent experiments from spaceflight and ground-based models have provided fresh insights into how these environmental stresses influence mechanisms that are related to redox signaling, oxidative stress, and tissue dysfunction. Emerging mechanistic knowledge on cellular defenses to radiation and other environmental stressors, including microgravity, are useful for both screening and developing interventions against spaceflight-induced deficits in bone and vascular function. View Full-Text
Keywords: spaceflight; bone; vasculature; oxidative stress; microgravity; hindlimb unloading; radiation; reactive oxygen species; antioxidant spaceflight; bone; vasculature; oxidative stress; microgravity; hindlimb unloading; radiation; reactive oxygen species; antioxidant
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Tahimic, C.G.T.; Globus, R.K. Redox Signaling and Its Impact on Skeletal and Vascular Responses to Spaceflight. Int. J. Mol. Sci. 2017, 18, 2153.

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