Next Article in Journal
PPARs Link Early Life Nutritional Insults to Later Programmed Hypertension and Metabolic Syndrome
Previous Article in Journal
Prediction of Protein Structural Class Based on Gapped-Dipeptides and a Recursive Feature Selection Approach
Open AccessReview

Epigenetic Regulation of Epidermal Stem Cell Biomarkers and Their Role in Wound Healing

1
Department of Biological Sciences, Alabama State University, Montgomery, AL 36104, USA
2
Department of Biology, University of Alabama at Birmingham, Birmingham, AL 35294-1170, USA
3
Clinical Nutrition Research Center, University of Alabama at Birmingham, Birmingham, AL 35294-1170, USA
4
Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL 35294-1170, USA
5
Center for Aging, University of Alabama at Birmingham, Birmingham, AL 35294-1170, USA
6
Nutrition Obesity Research Center, University of Alabama at Birmingham, Birmingham, AL 35294-1170, USA
*
Author to whom correspondence should be addressed.
Academic Editor: William Chi-shing Cho
Int. J. Mol. Sci. 2016, 17(1), 16; https://doi.org/10.3390/ijms17010016
Received: 7 November 2015 / Revised: 11 December 2015 / Accepted: 16 December 2015 / Published: 24 December 2015
(This article belongs to the Section Biochemistry)
As an actively renewable tissue, changes in skin architecture are subjected to the regulation of stem cells that maintain the population of cells responsible for the formation of epidermal layers. Stems cells retain their self-renewal property and express biomarkers that are unique to this population. However, differential regulation of the biomarkers can initiate the pathway of terminal cell differentiation. Although, pockets of non-clarity in stem cell maintenance and differentiation in skin still exist, the influence of epigenetics in epidermal stem cell functions and differentiation in skin homeostasis and wound healing is clearly evident. The focus of this review is to discuss the epigenetic regulation of confirmed and probable epidermal stem cell biomarkers in epidermal stratification of normal skin and in diseased states. The role of epigenetics in wound healing, especially in diseased states of diabetes and cancer, will also be conveyed. View Full-Text
Keywords: epigenetics; wound healing; skin; microRNA; epidermal stem cells; biomarkers epigenetics; wound healing; skin; microRNA; epidermal stem cells; biomarkers
Show Figures

Figure 1

MDPI and ACS Style

Saldanha, S.N.; Royston, K.J.; Udayakumar, N.; Tollefsbol, T.O. Epigenetic Regulation of Epidermal Stem Cell Biomarkers and Their Role in Wound Healing. Int. J. Mol. Sci. 2016, 17, 16.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop