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Open AccessArticle

Hesperidin, A Popular Antioxidant Inhibits Melanogenesis via Erk1/2 Mediated MITF Degradation

1
Department of Dermatology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Pyeong-dong, Jongno-gu, Seoul 110-746, Korea
2
Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, 388-1 Pungnap-dong Songpa-gu, Seoul 138-736, Korea
*
Authors to whom correspondence should be addressed.
Academic Editor: Maurizio Battino
Int. J. Mol. Sci. 2015, 16(8), 18384-18395; https://doi.org/10.3390/ijms160818384
Received: 13 May 2015 / Revised: 9 July 2015 / Accepted: 29 July 2015 / Published: 7 August 2015
Regulation of melanogenesis has been the focus of treatment for hyperpigmentary skin disorders. Although hesperidin is one of the most well-known, naturally occurring flavonoids with antioxidant and anti-inflammatory effect, its anti-melanogenic effect is not known. The present study aims to determine the anti-melanogenic effect of hespiridin as well as its underlying molecular mechanisms. Melanin contents were measured in normal human melanocytes and B16F10 melanoma cells. Protein and mRNA levels of tyrosinase, microphthalmia-associated transcription factor (MITF), tyrosinase related protein-1 (TRP-1) and TRP-2 were determined. Melanogenesis-regulating signals were examined. In results, hesperidin strongly inhibited melanin synthesis and tyrosinase activity. Hesperidin decreased tyrosinase, TRP-1, and TRP-2 protein expression but increased phospho-extracellular signal-regulated kinase 1/2 (p-Erk1/2) expression. Specific inhibitor of Erk1/2 or proteasome inhibitor reversed the inhibition of melanogenesis induced by hesperidin. Taken together, hesperidin, a popular antioxidant, stimulated Erk1/2 phosphorylation which subsequently degraded MITF which resulted in suppression of melanogenic enzymes and melanin synthesis. View Full-Text
Keywords: hesperidin; anti-melanogenesis; microphthalmia-associated transcription factor (MITF); extracellular signal-regulated kinase 1/2 (Erk1/2); antioxidant hesperidin; anti-melanogenesis; microphthalmia-associated transcription factor (MITF); extracellular signal-regulated kinase 1/2 (Erk1/2); antioxidant
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MDPI and ACS Style

Lee, H.J.; Lee, W.J.; Chang, S.E.; Lee, G.-Y. Hesperidin, A Popular Antioxidant Inhibits Melanogenesis via Erk1/2 Mediated MITF Degradation. Int. J. Mol. Sci. 2015, 16, 18384-18395.

AMA Style

Lee HJ, Lee WJ, Chang SE, Lee G-Y. Hesperidin, A Popular Antioxidant Inhibits Melanogenesis via Erk1/2 Mediated MITF Degradation. International Journal of Molecular Sciences. 2015; 16(8):18384-18395.

Chicago/Turabian Style

Lee, Heun J.; Lee, Woo J.; Chang, Sung E.; Lee, Ga-Young. 2015. "Hesperidin, A Popular Antioxidant Inhibits Melanogenesis via Erk1/2 Mediated MITF Degradation" Int. J. Mol. Sci. 16, no. 8: 18384-18395.

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