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Neurological and Epigenetic Implications of Nutritional Deficiencies on Psychopathology: Conceptualization and Review of Evidence

School of Nursing, University of Pennsylvania, 418 Curie Blvd., Philadelphia, PA 19104, USA
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Academic Editor: Lu Qi
Int. J. Mol. Sci. 2015, 16(8), 18129-18148; https://doi.org/10.3390/ijms160818129
Received: 5 May 2015 / Revised: 22 July 2015 / Accepted: 28 July 2015 / Published: 5 August 2015
(This article belongs to the Special Issue Gene-Nutrient Interactions)
In recent years, a role for epigenetic modifications in the pathophysiology of disease has received significant attention. Many studies are now beginning to explore the gene–environment interactions, which may mediate early-life exposure to risk factors, such as nutritional deficiencies and later development of behavioral problems in children and adults. In this paper, we review the current literature on the role of epigenetics in the development of psychopathology, with a specific focus on the potential for epigenetic modifications to link nutrition and brain development. We propose a conceptual framework whereby epigenetic modifications (e.g., DNA methylation) mediate the link between micro- and macro-nutrient deficiency early in life and brain dysfunction (e.g., structural aberration, neurotransmitter perturbation), which has been linked to development of behavior problems later on in life. View Full-Text
Keywords: molecular epigenetics; nutrients; brain dysfunction; gene–environment interactions; behavior problems; psychopathology; neurotoxicity molecular epigenetics; nutrients; brain dysfunction; gene–environment interactions; behavior problems; psychopathology; neurotoxicity
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Liu, J.; Zhao, S.R.; Reyes, T. Neurological and Epigenetic Implications of Nutritional Deficiencies on Psychopathology: Conceptualization and Review of Evidence. Int. J. Mol. Sci. 2015, 16, 18129-18148.

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