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Volume 30
Issue 19
10.3390/molecules30193899
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This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Article

The Pharmacokinetics, Bioavailability, and Excretion Studies of α-Cyperone in Rats by UHPLC-QQQ-MS/MS

by
Ye Shang
†,
Yameng Zhu
†,
Kaili Zhang
†,
Zijing Zhang
,
Huining Geng
,
Xueyu Liu
,
Wenwen Li
,
Lu Chen
,
Caixia Li
,
Yang Liu
,
Huizi Ouyang
and
Jun He
*
State Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
*
Author to whom correspondence should be addressed.
†
The author contributed equally to this work.
Molecules 2025, 30(19), 3899; https://doi.org/10.3390/molecules30193899
Submission received: 26 August 2025 / Revised: 24 September 2025 / Accepted: 25 September 2025 / Published: 26 September 2025
(This article belongs to the Section Analytical Chemistry)
Versions Notes

Abstract

α-Cyperone (C15H22O), a critical bioactive sesquiterpene, serves as a representative chemical compound of Cyperi Rhizoma—a classical functional food. To investigate the pharmacokinetic characteristics of α-cyperone, a quantified method was developed in plasma, bile, urine, and feces by ultra-high-performance liquid chromatography tandem triple quadrupole mass spectrometry (UHPLC-QQQ-MS/MS). After being validated, the developed method was applied in a plasma pharmacokinetic study as well as biliary, urinary, and fecal excretion kinetics studies. It revealed poor absolute bioavailability (F = 1.36%) and rare excretion (total cumulative excretion = 0.022%) of α-cyperone, which suggested extensive first-pass metabolism. This study provided crucial insight into explaining the in vivo process and promoting the further development of α-cyperone.
Keywords: α-cyperone; pharmacokinetic; bioavailability; excretion; UHPLC-QQQ-MS/MS α-cyperone; pharmacokinetic; bioavailability; excretion; UHPLC-QQQ-MS/MS

Share and Cite

MDPI and ACS Style

Shang, Y.; Zhu, Y.; Zhang, K.; Zhang, Z.; Geng, H.; Liu, X.; Li, W.; Chen, L.; Li, C.; Liu, Y.; et al. The Pharmacokinetics, Bioavailability, and Excretion Studies of α-Cyperone in Rats by UHPLC-QQQ-MS/MS. Molecules 2025, 30, 3899. https://doi.org/10.3390/molecules30193899

AMA Style

Shang Y, Zhu Y, Zhang K, Zhang Z, Geng H, Liu X, Li W, Chen L, Li C, Liu Y, et al. The Pharmacokinetics, Bioavailability, and Excretion Studies of α-Cyperone in Rats by UHPLC-QQQ-MS/MS. Molecules. 2025; 30(19):3899. https://doi.org/10.3390/molecules30193899

Chicago/Turabian Style

Shang, Ye, Yameng Zhu, Kaili Zhang, Zijing Zhang, Huining Geng, Xueyu Liu, Wenwen Li, Lu Chen, Caixia Li, Yang Liu, and et al. 2025. "The Pharmacokinetics, Bioavailability, and Excretion Studies of α-Cyperone in Rats by UHPLC-QQQ-MS/MS" Molecules 30, no. 19: 3899. https://doi.org/10.3390/molecules30193899

APA Style

Shang, Y., Zhu, Y., Zhang, K., Zhang, Z., Geng, H., Liu, X., Li, W., Chen, L., Li, C., Liu, Y., Ouyang, H., & He, J. (2025). The Pharmacokinetics, Bioavailability, and Excretion Studies of α-Cyperone in Rats by UHPLC-QQQ-MS/MS. Molecules, 30(19), 3899. https://doi.org/10.3390/molecules30193899

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