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Microwave-Assisted Synthesis, Structural Characterization and Assessment of the Antibacterial Activity of Some New Aminopyridine, Pyrrolidine, Piperidine and Morpholine Acetamides

Department of Chemistry, College of Applied Sciences, University of Samarra, Salahaldin 13/1333, Iraq
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Academic Editor: Diego Muñoz-Torrero
Molecules 2021, 26(3), 533; https://doi.org/10.3390/molecules26030533
Received: 28 September 2020 / Revised: 9 November 2020 / Accepted: 11 November 2020 / Published: 20 January 2021
A series of new acetamide derivatives 2228 of primary and secondary amines and para-toluene sulphinate sodium salt have been synthesized under microwave irradiation and assessed in vitro for their antibacterial activity against one Gram-positive and two Gram-negative bacterial species such as S. pyogenes, E. coli, and P. mirabilis using the Mueller-Hinton Agar diffusion (well diffusion) method. The synthesized compounds with significant differences in inhibition diameters and MICs were compared with those of amoxicillin, ampicillin, cephalothin, azithromycin and doxycycline. All of the evaluated acetamide derivatives were used with varying inhibition concentrations of 6.25, 12.5, 37.5, 62.5, 87.5, 112.5 and 125 µg/mL. The results show that the most important antibacterial properties were displayed by the synthetic compounds 22 and 24, both of bear a para-chlorophenyl moiety incorporated into the 2-position moiety of acetamide 1. The molecular structures of the new compounds were determined using the FT-IR and 1H-NMR techniques. View Full-Text
Keywords: acetamide; pyridine; pyrrolidine; piperidine; morpholine; antibacterial activity; heterocycles acetamide; pyridine; pyrrolidine; piperidine; morpholine; antibacterial activity; heterocycles
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MDPI and ACS Style

Alsamarrai, A.S.H.; Abdulghani, S.S. Microwave-Assisted Synthesis, Structural Characterization and Assessment of the Antibacterial Activity of Some New Aminopyridine, Pyrrolidine, Piperidine and Morpholine Acetamides. Molecules 2021, 26, 533. https://doi.org/10.3390/molecules26030533

AMA Style

Alsamarrai ASH, Abdulghani SS. Microwave-Assisted Synthesis, Structural Characterization and Assessment of the Antibacterial Activity of Some New Aminopyridine, Pyrrolidine, Piperidine and Morpholine Acetamides. Molecules. 2021; 26(3):533. https://doi.org/10.3390/molecules26030533

Chicago/Turabian Style

Alsamarrai, Abdulmajeed S.H.; Abdulghani, Saba S. 2021. "Microwave-Assisted Synthesis, Structural Characterization and Assessment of the Antibacterial Activity of Some New Aminopyridine, Pyrrolidine, Piperidine and Morpholine Acetamides" Molecules 26, no. 3: 533. https://doi.org/10.3390/molecules26030533

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