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Article

Piperine Ameliorates Trimellitic Anhydride-Induced Atopic Dermatitis-Like Symptoms by Suppressing Th2-Mediated Immune Responses via Inhibition of STAT6 Phosphorylation

1
Food Biotechnology Program, Korea University of Science and Technology, Daejeon 34113, Korea
2
Division of Functional Food Research, Korea Food Research Institute, 245, Nongsaengmyeong-ro, Iseo-myeon, Wanju-gun, Jeollabuk-do 55365, Korea
3
Department of Food Processing and Distribution, Gangneung-Wonju National University, Gangneung, Gangwon-do 25457, Korea
*
Author to whom correspondence should be addressed.
Academic Editor: Juraj Majtan
Molecules 2020, 25(9), 2186; https://doi.org/10.3390/molecules25092186
Received: 5 April 2020 / Revised: 29 April 2020 / Accepted: 5 May 2020 / Published: 7 May 2020
(This article belongs to the Special Issue Natural Products and Skin Diseases)
Atopic dermatitis (AD) is a common inflammatory skin disease predominately related to Type 2 helper T (Th2) immune responses. In this study, we investigated whether piperine is able to improve AD symptoms using a trimellitic anhydride (TMA)-induced AD-like mouse model. Topical treatment with piperine reduced ear swelling (ear thickness and epidermal thickness) induced by TMA exposure. Furthermore, piperine inhibited pro-inflammatory cytokines such as TNF-α and IL-1β in mouse ears, compared with the TMA-induced AD group. In measuring allergic immune responses in draining lymph nodes (dLNs), we found that IL-4 secretion, GATA3 mRNA level, and STAT6 phosphorylation were suppressed by piperine treatment. In an ex vivo study, piperine also inhibited the phosphorylation of STAT6 on the CD4+ T cells isolated from splenocytes of BALB/c mice, and piperine suppressed IL-4-induced CCL26 mRNA expression and STAT6 phosphorylation in human keratinocytes resulting in the inhibition of infiltration of CCR3+ cells into inflammatory lesions. These results demonstrate that piperine could ameliorate AD symptoms through suppression of Th2-mediated immune responses, including the STAT6/GATA3/IL-4 signaling pathway. Therefore, we suggest that piperine is an excellent candidate as an inhibitor of STAT6 and may help to improve AD symptoms. View Full-Text
Keywords: piperine; atopic dermatitis; Th2 immune response; CCR3; STAT6 piperine; atopic dermatitis; Th2 immune response; CCR3; STAT6
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MDPI and ACS Style

Choi, D.W.; Jung, S.Y.; Shon, D.-H.; Shin, H.S. Piperine Ameliorates Trimellitic Anhydride-Induced Atopic Dermatitis-Like Symptoms by Suppressing Th2-Mediated Immune Responses via Inhibition of STAT6 Phosphorylation. Molecules 2020, 25, 2186. https://doi.org/10.3390/molecules25092186

AMA Style

Choi DW, Jung SY, Shon D-H, Shin HS. Piperine Ameliorates Trimellitic Anhydride-Induced Atopic Dermatitis-Like Symptoms by Suppressing Th2-Mediated Immune Responses via Inhibition of STAT6 Phosphorylation. Molecules. 2020; 25(9):2186. https://doi.org/10.3390/molecules25092186

Chicago/Turabian Style

Choi, Dae W., Sun Y. Jung, Dong-Hwa Shon, and Hee S. Shin 2020. "Piperine Ameliorates Trimellitic Anhydride-Induced Atopic Dermatitis-Like Symptoms by Suppressing Th2-Mediated Immune Responses via Inhibition of STAT6 Phosphorylation" Molecules 25, no. 9: 2186. https://doi.org/10.3390/molecules25092186

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