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Open AccessReview

A Review of Cytotoxic Plants of the Indian Subcontinent and a Broad-Spectrum Analysis of Their Bioactive Compounds

Department of Pharmacy, Jashore University of Science and Technology, Jashore 7408, Bangladesh
School of Biomedical Sciences, Charles Sturt University, Boorooma St, Locked Bag 588, Wagga Wagga, New South Wales 2678, Australia
Department of Chemistry, Graduate School of Science, Osaka University, Osaka 565-0871, Japan
Authors to whom correspondence should be addressed.
Academic Editor: Luisa Tesoriere
Molecules 2020, 25(8), 1904;
Received: 7 March 2020 / Revised: 15 April 2020 / Accepted: 16 April 2020 / Published: 20 April 2020
(This article belongs to the Special Issue Cytotoxic Activity of Plant Extracts)
Cancer or uncontrolled cell proliferation is a major health issue worldwide and is the second leading cause of deaths globally. The high mortality rate and toxicity associated with cancer chemotherapy or radiation therapy have encouraged the investigation of complementary and alternative treatment methods, such as plant-based drugs. Moreover, over 60% of the anti-cancer drugs are molecules derived from plants or their synthetic derivatives. Therefore, in the present review, an attempt has been made to summarize the cytotoxic plants available in the Indian subcontinent along with a description of their bio-active components. The review covers 99 plants of 57 families as well as over 110 isolated bioactive cytotoxic compounds, amongst which at least 20 are new compounds. Among the reported phytoconstituents, artemisinin, lupeol, curcumin, and quercetin are under clinical trials, while brazilin, catechin, ursolic acid, β-sitosterol, and myricetin are under pharmacokinetic development. However, for the remaining compounds, there is little or no information available. Therefore, further investigations are warranted on these subcontinent medicinal plants as an important source of novel cytotoxic agents. View Full-Text
Keywords: anticancer; cytotoxic; Indian subcontinent plants; bioactive compounds anticancer; cytotoxic; Indian subcontinent plants; bioactive compounds
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Mazumder, K.; Biswas, B.; Raja, I.M.; Fukase, K. A Review of Cytotoxic Plants of the Indian Subcontinent and a Broad-Spectrum Analysis of Their Bioactive Compounds. Molecules 2020, 25, 1904.

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