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Open AccessFeature PaperArticle

Ion-Trap Mass Spectrometric Analysis of Bisphenol A Interactions With Titanium Dioxide Nanoparticles and Milk Proteins

1
Ottawa-Carleton Chemistry Institute, Department of Chemistry, Carleton University, Ottawa, ON K1S 5B6, Canada
2
Institute for Pure and Applied Mass Spectrometry, Physical and Theoretical Chemistry, Bergische Universität Wuppertal, Gaussstr. 20, 42119 Wuppertal, Germany
*
Author to whom correspondence should be addressed.
Academic Editor: Adnan Younis
Molecules 2020, 25(3), 708; https://doi.org/10.3390/molecules25030708
Received: 4 January 2020 / Revised: 27 January 2020 / Accepted: 5 February 2020 / Published: 6 February 2020
(This article belongs to the Special Issue Oxide Nanomaterial)
Quantitative analysis of endocrine-disrupting molecules such as bisphenol A (BPA) in freshwater to determine their widespread occurrence in environmental resources has been challenged by various adsorption and desorption processes. In this work, ion trap mass spectrometry (ITMS) analysis of BPA was aimed at studying its molecular interactions with titanium dioxide (TiO2) nanoparticles and milk whey proteins. Addition of sodium formate prevented TiO2 nanoparticles from sedimentation while enhancing the electrospray ionization (ESI) efficiency to produce an abundance of [BPA + Na]+ ions at m/z 251.0. More importantly, the ESI-ITMS instrument could operate properly during a direct infusion of nanoparticles up to 500 μg/mL without clogging the intake capillary. Milk protein adsorption of BPA could decrease the [BPA + Na]+ peak intensity significantly unless the proteins were partially removed by curdling to produce whey, which allowed BPA desorption during ESI for quantitative analysis by ITMS. View Full-Text
Keywords: bisphenol A; ion-trap mass spectrometry; milk whey proteins; sodium formate; titanium dioxide nanoparticles bisphenol A; ion-trap mass spectrometry; milk whey proteins; sodium formate; titanium dioxide nanoparticles
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MDPI and ACS Style

Lai, E.P.; Kersten, H.; Benter, T. Ion-Trap Mass Spectrometric Analysis of Bisphenol A Interactions With Titanium Dioxide Nanoparticles and Milk Proteins. Molecules 2020, 25, 708.

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