Next Article in Journal
LC-MS-Based Metabolomics for the Chemosystematics of Kenyan Dodonaea viscosa Jacq (Sapindaceae) Populations
Next Article in Special Issue
In Vitro Antimicrobial Activity of Isopimarane-Type Diterpenoids
Previous Article in Journal
Effect of Molecular Crowding on DNA Polymerase Reactions along Unnatural DNA Templates
Previous Article in Special Issue
Advances on Antiviral Activity of Morus spp. Plant Extracts: Human Coronavirus and Virus-Related Respiratory Tract Infections in the Spotlight
Open AccessArticle

Glucose-Uptake Activity and Cytotoxicity of Diterpenes and Triterpenes Isolated from Lamiaceae Plant Species

1
Department of Horticultural Sciences, Cape Peninsula University of Technology, Symphony Rd., Bellville 7535, South Africa
2
Chemistry Department, Cape Peninsula University of Technology, Symphony Rd., Bellville 7535, South Africa
3
Precision Medicine Laboratory, Department of Biotechnology, 2nd Floor, Life Science Building, University of the Western Cape, Cape Town 7530, South Africa
4
Chemistry Department, University of the Western Cape, Private Bag X17, Bellville 7535, South Africa
*
Author to whom correspondence should be addressed.
Academic Editors: Patrícia Rijo, Vera Isca and Daniele Passarella
Molecules 2020, 25(18), 4129; https://doi.org/10.3390/molecules25184129
Received: 17 July 2020 / Revised: 11 August 2020 / Accepted: 14 August 2020 / Published: 10 September 2020
(This article belongs to the Special Issue Design of Natural Products Lead Molecules Using Organic Synthesis)
The prevalence of diabetes mellitus (DM), considered one of the most common metabolic disorders, has dramatically increased and resulted in higher rates of morbidity and mortality around the world in the past decade. It is well known that insulin resistance in target tissues and a deficiency in insulin secretion from pancreatic β-cells are the main characteristics of type 2 diabetes. The aim of this study was the bio-evaluation of compounds isolated from three selected plant species: namely, Salvia africana-lutea, Leonotis ocymifolia, and Plectranthus madagascariensis, for their glucose-uptake ability. Methanolic extracts were produced from the aerial parts of each plant. Compounds were identified using different spectroscopic techniques. The glucose-uptake ability of each compound was then evaluated in mammalian cells using 2-deoxyglucose-6-phosphate. The cytotoxicity of each compound was established via the MTT assay. Chromatographic purification of the three plant species yielded sixteen pure terpenoids. Compounds 1 (p = 0.0031), 8 (p = 0.0053), and 6 (p = 0.0086) showed a marked increase in glucose uptake, respectively. Additionally, 1, 4, and 6 exhibited cytotoxicity toward mammalian tissue with a decrease in cell viability of ~70%, ~68%, and ~67%, respectively. The results suggested that several compounds demonstrated a marked increase in glucose uptake, while two of the compounds exhibited signs of cytotoxicity. It may, therefore, be suggested that these compounds be considered as potential candidates for novel plant-derived alternative therapies in the treatment of type 2 diabetes. View Full-Text
Keywords: diabetes mellitus; Lamiaceae; terpenoids; abietane diterpenes; ursolic acid; glucose uptake; toxicity; insulin resistance diabetes mellitus; Lamiaceae; terpenoids; abietane diterpenes; ursolic acid; glucose uptake; toxicity; insulin resistance
Show Figures

Figure 1

MDPI and ACS Style

Etsassala, N.G.E.R.; Ndjoubi, K.O.; Mbira, T.J.; Pearce, B.; Pearce, K.; Iwuoha, E.I.; Hussein, A.A.; Benjeddou, M. Glucose-Uptake Activity and Cytotoxicity of Diterpenes and Triterpenes Isolated from Lamiaceae Plant Species. Molecules 2020, 25, 4129.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop