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Article

Neuroprotective Effects of Cryptotanshinone in a Direct Reprogramming Model of Parkinson’s Disease

1
Stem Cell Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 34141, Korea
2
Department of Functional Genomics, KRIBB School of Bioscience, University of Science and Technology, Daejeon 34113, Korea
3
Group for Biometrology, Korea Research Institute of Standards and Science (KRISS), Daejeon 34113, Korea
4
Huen Co., Ltd., Gwanggyo Business Center 5F (#508), 156, Gwanggyo-ro, Yeongtong-gu, Suwon 16506, Korea
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Molecules 2020, 25(16), 3602; https://doi.org/10.3390/molecules25163602
Received: 21 July 2020 / Revised: 2 August 2020 / Accepted: 5 August 2020 / Published: 7 August 2020
Parkinson’s disease (PD) is a well-known age-related neurodegenerative disease. Considering the vital importance of disease modeling based on reprogramming technology, we adopted direct reprogramming to human-induced neuronal progenitor cells (hiNPCs) for in vitro assessment of potential therapeutics. In this study, we investigated the neuroprotective effects of cryptotanshinone (CTN), which has been reported to have antioxidant properties, through PD patient-derived hiNPCs (PD-iNPCs) model with induced oxidative stress and cell death by the proteasome inhibitor MG132. A cytotoxicity assay showed that CTN possesses anti-apoptotic properties in PD-hiNPCs. CTN treatment significantly reduced cellular apoptosis through mitochondrial restoration, such as the reduction in mitochondrial reactive oxygen species and increments of mitochondrial membrane potential. These effects of CTN are mediated via the nuclear factor erythroid 2-related factor 2 (NRF2) pathway in PD-hiNPCs. Consequently, CTN could be a potential antioxidant reagent for preventing disease-related pathological phenotypes of PD. View Full-Text
Keywords: Parkinson’s disease; cryptotanshinone; disease modeling; mitochondrial dysfunction; antioxidant Parkinson’s disease; cryptotanshinone; disease modeling; mitochondrial dysfunction; antioxidant
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MDPI and ACS Style

Lee, J.-E.; Sim, H.; Yoo, H.M.; Lee, M.; Baek, A.; Jeon, Y.-J.; Seo, K.-S.; Son, M.-Y.; Yoon, J.S.; Kim, J. Neuroprotective Effects of Cryptotanshinone in a Direct Reprogramming Model of Parkinson’s Disease. Molecules 2020, 25, 3602. https://doi.org/10.3390/molecules25163602

AMA Style

Lee J-E, Sim H, Yoo HM, Lee M, Baek A, Jeon Y-J, Seo K-S, Son M-Y, Yoon JS, Kim J. Neuroprotective Effects of Cryptotanshinone in a Direct Reprogramming Model of Parkinson’s Disease. Molecules. 2020; 25(16):3602. https://doi.org/10.3390/molecules25163602

Chicago/Turabian Style

Lee, Joo-Eun, Hyuna Sim, Hee Min Yoo, Minhyung Lee, Aruem Baek, Young-Joo Jeon, Kang-Sik Seo, Mi-Young Son, Joo Seog Yoon, and Janghwan Kim. 2020. "Neuroprotective Effects of Cryptotanshinone in a Direct Reprogramming Model of Parkinson’s Disease" Molecules 25, no. 16: 3602. https://doi.org/10.3390/molecules25163602

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