Impact of Lipid Sources on Quality Traits of Medical Cannabis-Based Oil Preparations
by
Alberto Ramella 1, Gabriella Roda 2, Radmila Pavlovic 3,*, Michele Dei Cas 4
, Eleonora Casagni 2, Giacomo Mosconi 3, Francisco Cecati 5, Paola Minghetti 2 and Carlo Grizzetti 6
Alberto Ramella 1, Gabriella Roda 2, Radmila Pavlovic 3,*, Michele Dei Cas 4, Eleonora Casagni 2, Giacomo Mosconi 3, Francisco Cecati 5, Paola Minghetti 2 and Carlo Grizzetti 6
1
Farmacia Dott.ri Giuliana e Alberto Ramella–SAS, Via A. Diaz 1, 21021 Angera (VA), Italy
2
Department of Pharmaceutical Sciences, Università degli Studi di Milano, Via L. Mangiagalli 25, 20133 Milan, Italy
3
Department of Health, Animal Science and Food Safety, University of Milan, 20133 Milan, Italy
4
Department of Health Sciences, Università degli Studi di Milano, Via A.di Rudinì 8, 20142 Milan, Italy
5
INTEQUI-CONICET, Faculty of Chemistry, Biochemistry and Pharmacy, National University of San Luis, Almirante Brown 1455, San Luis CP 5700, Argentina
6
S.S.D. Cure Palliative e Terapia del Dolore, Ospedale di Circolo–Fondazione Macchi, ASST Sette Laghi, Viale L. Borri 57, 21100 Varese, Italy
*
Author to whom correspondence should be addressed.
Academic Editor: Maria Carla Marcotullio
Molecules 2020, 25(13), 2986; https://doi.org/10.3390/molecules25132986 (registering DOI)
Received: 2 June 2020 / Revised: 27 June 2020 / Accepted: 29 June 2020 / Published: 30 June 2020
(This article belongs to the Collection Qualitative and Quantitative Analysis of Bioactive Natural Products)
The feasibility of the use of two lipid sources and their impact on the cannabinoid profile, terpene fingerprint, and degradation products in medical cannabis oil preparations during 3 months of refrigerated storage time were investigated. LCHRMS-Orbitrap® and HS-SPME coupled to GC-MS for the investigation of targeted and untargeted cannabinoids, terpenes, and lipid degradation products in Bedrocan® and Bediol® macerated oils were used as analytical approaches. As regards the cannabinoid trend during 90 days of storage, there were no differences between PhEur-grade olive oil (OOPH) and medium-chain triglycerides oil (MCT oil) coupled to a good stability of preparations for the first 60 days both in Bedrocan® and Bediol® oils. MCT lipid source extracted a significant concentration of terpenes compared to olive oil. Terpenes showed a different scenario since MCT oil displayed the strongest extraction capacity and conservation trend of all compounds during the shelf life. Terpenes remained stable throughout the entire storage period in MCT formulations while a significant decrease after 15 and 30 days in Bediol® and Bedrocan® was observed in olive oil. Therefore, MCT oil could be considered a more suitable lipid source compared to olive oil involved in the extraction of medical cannabis for magistral preparations.
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Keywords:
cannabis oils; cannabinoids; terpenes; LCHRMS-Orbitrap; HS-SPME-GC/MS; olive oil; MCT oil
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MDPI and ACS Style
Ramella, A.; Roda, G.; Pavlovic, R.; Dei Cas, M.; Casagni, E.; Mosconi, G.; Cecati, F.; Minghetti, P.; Grizzetti, C. Impact of Lipid Sources on Quality Traits of Medical Cannabis-Based Oil Preparations. Molecules 2020, 25, 2986.
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