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Zebrafish-Based Screening Models for the Identification of Anti-Metastatic Drugs

Shonai Regional Industry Promotion Center, Tsuruoka, Yamagata 997-0052, Japan
Tsuruoka Metabolomics Laboratory, National Cancer Center, Mizukami 246-2, Kakuganji, Tsuruoka, Yamagata 975-0052, Japan
Division of Translational Research, Exploratory Oncology Research, and Clinical Trial Center, National Cancer Center, Kashiwa, Chiba 277-8577, Japan
Author to whom correspondence should be addressed.
Academic Editors: Yasuhito Shimada and Herman P. Spaink
Molecules 2020, 25(10), 2407;
Received: 31 March 2020 / Revised: 18 May 2020 / Accepted: 19 May 2020 / Published: 21 May 2020
(This article belongs to the Special Issue Zebrafish-Based Drug Screening)
Metastasis, a leading contributor to the morbidity of cancer patients, occurs through a multi-step process: invasion, intravasation, extravasation, colonization, and metastatic tumor formation. Each process is not only promoted by cancer cells themselves but is also affected by their microenvironment. Given this complexity, drug discovery for anti-metastatic drugs must consider the interaction between cancer cells and their microenvironments. The zebrafish is a suitable vertebrate animal model for in vivo high-throughput screening studies with physiological relevance to humans. This review covers the zebrafish model used to identify anti-metastatic drugs. View Full-Text
Keywords: zebrafish; metastasis; EMT; angiogenesis; phenotyping screening zebrafish; metastasis; EMT; angiogenesis; phenotyping screening
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Nakayama, J.; Makinoshima, H. Zebrafish-Based Screening Models for the Identification of Anti-Metastatic Drugs. Molecules 2020, 25, 2407.

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