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Open AccessArticle

Anti-Inflammatory and Cytotoxic Potential of New Phenanthrenoids from Luzula sylvatica

1
Université Clermont-Auvergne, CNRS, SIGMA Clermont, ICCF, F-63000 Clermont-Ferrand, France
2
Université Clermont-Auvergne, INRA, UNH, Unité de Nutrition Humaine, CRNH Auvergne, F-63000 Clermont-Ferrand, France
3
Pharmaceutical Biology, Pharmacenter, University of Basel, Klingelbergstrasse 50, 4056 Basel, Switzerland
4
Greentech, Biopôle Clermont-Limagne, 63360 Saint-Beauzire, France
5
Dômes Pharma, 3 Rue André Citroën, 63430 Pont-du-Château, France
6
AltoPhyto, 7 rue des Gargailles, 63370 Lempdes, France
*
Authors to whom correspondence should be addressed.
Academic Editor: Rob Keyzers
Molecules 2020, 25(10), 2372; https://doi.org/10.3390/molecules25102372
Received: 21 April 2020 / Revised: 17 May 2020 / Accepted: 19 May 2020 / Published: 20 May 2020
(This article belongs to the Special Issue New Approaches for the Isolation of Natural Products)
Phenanthrenoids have been widely described, in the Juncaceae family, for their biological properties such as antitumor, anxiolytic, anti-microbial, spasmolytic, and anti-inflammatory activities. The Juncaceae family is known to contain a large variety of phenanthrenoids possessing especially anti-inflammatory and cytotoxic properties. Luzula sylvatica, a Juncaceae species, is widely present in the Auvergne region of France, but has never been studied neither for its phytochemical profile nor for its biological properties. We investigated the phytochemical profile and evaluated the potential anti-inflammatory activities of L. sylvatica aerial parts extracts. A bioassay-guided fractionation was carried out to identify the most active fractions. Nine compounds were isolated, one coumarin 1 and eight phenanthrene derivatives (29), including four new compounds (4, 5, 8 and 9), from n-hexane and CH2Cl2, fractions. Their structures were established by HRESIMS, 1D and 2D NMR experiments. The biological properties, especially the anti-inflammatory/antioxidant activities (ROS production) and antiproliferative activity on THP-1, a monocytic leukemia cell line, of each compound, were evaluated. Three phenanthrene derivatives 4, 6, and 7 showed very promising antiproliferative activities. View Full-Text
Keywords: phenanthrene derivatives; antiproliferative activities; Luzula sylvatica phenanthrene derivatives; antiproliferative activities; Luzula sylvatica
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MDPI and ACS Style

Gainche, M.; Ripoche, I.; Senejoux, F.; Cholet, J.; Ogeron, C.; Decombat, C.; Danton, O.; Delort, L.; Vareille-Delarbre, M.; Berry, A.; Vermerie, M.; Fraisse, D.; Felgines, C.; Ranouille, E.; Berthon, J.-Y.; Priam, J.; Saunier, E.; Tourrette, A.; Troin, Y.; Caldefie-Chezet, F.; Chalard, P. Anti-Inflammatory and Cytotoxic Potential of New Phenanthrenoids from Luzula sylvatica. Molecules 2020, 25, 2372.

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