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Open AccessArticle

Green Methodologies for Copper(I)-Catalyzed Azide-Alkyne Cycloadditions: A Comparative Study

Department of Chemistry and Biochemistry, University of Colorado Colorado Springs, Colorado Springs, CO 80918, USA
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Academic Editor: John Spencer
Molecules 2019, 24(5), 973; https://doi.org/10.3390/molecules24050973
Received: 1 February 2019 / Revised: 27 February 2019 / Accepted: 1 March 2019 / Published: 10 March 2019
(This article belongs to the Special Issue Microwave-Mediated Chemistry)
Successful copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) reactions may be achieved by several methods. In this paper, four synthetic protocols were performed for direct comparison of time required for the synthesis, yield, and purity of the 1H-1,2,3-triazole products. The methods with Cu(I) catalysts were conventional, microwave heating, solvent-free, and a method using glycerol solvent. The compounds synthesized in this paper were known non-fluorinated triazoles and new fluorinated triazoles. The results lead to the conclusion that the microwave method should be strongly considered for CuAAC syntheses. View Full-Text
Keywords: 1H-1,2,3-triazole; copper-catalyzed azide-alkyne cycloaddition (CuAAC); microwave heating; solvent-free reaction; green chemistry; fluorotriazole 1H-1,2,3-triazole; copper-catalyzed azide-alkyne cycloaddition (CuAAC); microwave heating; solvent-free reaction; green chemistry; fluorotriazole
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MDPI and ACS Style

Trujillo, M.; Hull-Crew, C.; Outlaw, A.; Stewart, K.; Taylor, L.; George, L.; Duensing, A.; Tracey, B.; Schoffstall, A. Green Methodologies for Copper(I)-Catalyzed Azide-Alkyne Cycloadditions: A Comparative Study. Molecules 2019, 24, 973.

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