Next Article in Journal
Differentiation of Fresh and Processed Fruit Juices Using Volatile Composition
Previous Article in Journal
Effects of a Lysine-Involved Maillard Reaction on the Structure and In Vitro Activities of Polysaccharides from Longan Pulp
Previous Article in Special Issue
Microwave-Assisted Synthesis of Mono- and Disubstituted 4-Hydroxyacetophenone Derivatives via Mannich Reaction: Synthesis, XRD and HS-Analysis
Article Menu
Issue 5 (March-1) cover image

Export Article

Open AccessArticle
Molecules 2019, 24(5), 973; https://doi.org/10.3390/molecules24050973

Green Methodologies for Copper(I)-Catalyzed Azide-Alkyne Cycloadditions: A Comparative Study

Department of Chemistry and Biochemistry, University of Colorado Colorado Springs, Colorado Springs, CO 80918, USA
*
Author to whom correspondence should be addressed.
Academic Editor: John Spencer
Received: 1 February 2019 / Revised: 27 February 2019 / Accepted: 1 March 2019 / Published: 10 March 2019
(This article belongs to the Special Issue Microwave-mediated Chemistry)
Full-Text   |   PDF [775 KB, uploaded 10 March 2019]   |  

Abstract

Successful copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) reactions may be achieved by several methods. In this paper, four synthetic protocols were performed for direct comparison of time required for the synthesis, yield, and purity of the 1H-1,2,3-triazole products. The methods with Cu(I) catalysts were conventional, microwave heating, solvent-free, and a method using glycerol solvent. The compounds synthesized in this paper were known non-fluorinated triazoles and new fluorinated triazoles. The results lead to the conclusion that the microwave method should be strongly considered for CuAAC syntheses. View Full-Text
Keywords: 1H-1,2,3-triazole; copper-catalyzed azide-alkyne cycloaddition (CuAAC); microwave heating; solvent-free reaction; green chemistry; fluorotriazole 1H-1,2,3-triazole; copper-catalyzed azide-alkyne cycloaddition (CuAAC); microwave heating; solvent-free reaction; green chemistry; fluorotriazole
Figures

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Supplementary material

SciFeed

Share & Cite This Article

MDPI and ACS Style

Trujillo, M.; Hull-Crew, C.; Outlaw, A.; Stewart, K.; Taylor, L.; George, L.; Duensing, A.; Tracey, B.; Schoffstall, A. Green Methodologies for Copper(I)-Catalyzed Azide-Alkyne Cycloadditions: A Comparative Study. Molecules 2019, 24, 973.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top