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Open AccessArticle

The Effects of Different Varieties of Aurantii Fructus Immaturus on the Potential Toxicity of Zhi-Zi-Hou-Po Decoction Based on Spectrum-Toxicity Correlation Analysis

by Qianqian Zhang 1 and Fang Feng 1,2,*
1
Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing 210009, China
2
Key Laboratory of Drug Quality Control and Pharmacovigilance, Ministry of Education, China Pharmaceutical University, Nanjing 210009, China
*
Author to whom correspondence should be addressed.
Academic Editor: Francesco Cacciola
Molecules 2019, 24(23), 4254; https://doi.org/10.3390/molecules24234254
Received: 10 October 2019 / Revised: 19 November 2019 / Accepted: 20 November 2019 / Published: 22 November 2019
In accordance with the provision in China Pharmacopoeia, Citrus aurantium L. (Sour orange—SZS) and Citrus sinensis Osbeck (Sweet orange—TZS) are all in line with the requirements of Aurantii Fructus Immaturus (ZS). Both kinds of ZS are also marketed in the market. With the frequent occurrence of depression, Zhi-Zi-Hou-Po decoction (ZZHPD) has attracted wide attention. Currently, studies have shown that ZZHPD has a potential toxicity risk, but the effect of two commercial varieties of ZS on ZZHPD has not been reported. In this study, the toxicity differences of ZZHPD prepared by SZS and TZS were revealed through repeated administration experiments in rats. This indicated that different varieties of ZS could affect the toxicity of the prescription. In order to further study the chemical material basis of the toxicity difference, the fingerprints of ZZHPD prepared by different varieties of ZS were established by high-performance liquid chromatography (HPLC). Five different characteristic peaks were screened by non-target chemometrics. They were identified as geniposide, neoeriocitrin, naringin, hesperidin, and neohesperidin using an HPLC-time-of-flight mass spectrometry analyzer (TOF/MS) and an HPLC-triple stage quadrupole mass spectrometry analyzer (QqQ-MS/MS). Combined with a quantitative analysis and previous studies on promoting the intestinal absorption of geniposide, it is speculated that the synergistic effects of the components may be the main reason for the difference of toxicity among the different medicinal materials. This study provides a reference for the clinical, safe use of ZZHPD, and also provides a new perspective for the study of the potential toxic substances of traditional Chinese medicine compound preparations. View Full-Text
Keywords: Zhi-Zi-Hou-Po decoction; spectrum–toxicity correlation analysis; synergistic effect; multivariate statistical analysis; potential toxicity Zhi-Zi-Hou-Po decoction; spectrum–toxicity correlation analysis; synergistic effect; multivariate statistical analysis; potential toxicity
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MDPI and ACS Style

Zhang, Q.; Feng, F. The Effects of Different Varieties of Aurantii Fructus Immaturus on the Potential Toxicity of Zhi-Zi-Hou-Po Decoction Based on Spectrum-Toxicity Correlation Analysis. Molecules 2019, 24, 4254.

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