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Anthocyanins Potentially Contribute to Defense against Alzheimer’s Disease

Biological Sciences Department, Faculty of Science, Kuwait University, Safat-13060, Kuwait
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Academic Editors: Takanori Tsuda and Wilhelmina Kalt
Molecules 2019, 24(23), 4255; https://doi.org/10.3390/molecules24234255
Received: 25 September 2019 / Revised: 31 October 2019 / Accepted: 5 November 2019 / Published: 22 November 2019
(This article belongs to the Special Issue Anthocyanins: Recent Progress in Health Benefits Studies)
Anthocyanins (ANTs) are plant pigments that belong to a flavanol class of polyphenols and have diverse pharmacological properties. These compounds are primarily found in fruits and vegetables, with an average daily intake of 180 mgd−1 of these compounds in the developed world. ANTs are potent antioxidants that might regulate the free radical-mediated generation of amyloid peptides (Abeta-amyloids) in the brain, which causes Alzheimer’s disease (AD). This study presents a literature review of ANTs from different berries and their potential therapeutic value, with particular emphasis on neurodegenerative AD, which owing to oxidative stress. This review also highlights reactive oxygen species (ROS) generation through energy metabolism, nitrogen reactive species, the role of transition metals in generating ROS, and the radical-quenching mechanisms of natural antioxidants, including ANTs. The current status of the bioavailability, solubility, and structure activity relationship of ANTs is discussed herein. View Full-Text
Keywords: anthocyanins; antioxidants; transition metals; reactive oxygen species anthocyanins; antioxidants; transition metals; reactive oxygen species
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MDPI and ACS Style

Afzal, M.; Redha, A.; AlHasan, R. Anthocyanins Potentially Contribute to Defense against Alzheimer’s Disease. Molecules 2019, 24, 4255. https://doi.org/10.3390/molecules24234255

AMA Style

Afzal M, Redha A, AlHasan R. Anthocyanins Potentially Contribute to Defense against Alzheimer’s Disease. Molecules. 2019; 24(23):4255. https://doi.org/10.3390/molecules24234255

Chicago/Turabian Style

Afzal, Mohammad; Redha, Amina; AlHasan, Redha. 2019. "Anthocyanins Potentially Contribute to Defense against Alzheimer’s Disease" Molecules 24, no. 23: 4255. https://doi.org/10.3390/molecules24234255

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