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Synthesis of 1,2,3-Triazolium Ionic Liquid-Supported Chiral Imidazolidinones and Their Application in Asymmetric Alkylation Reaction

College of Pharmacy & Graduate School of Pharmaceutical Sciences, Ewha Womans University, 52 Ewhayeodae-gil, Seodaemun-Gu, Seoul 03760, Korea
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Academic Editor: Wim Dehaen
Molecules 2019, 24(18), 3349; https://doi.org/10.3390/molecules24183349
Received: 19 August 2019 / Revised: 11 September 2019 / Accepted: 13 September 2019 / Published: 14 September 2019
(This article belongs to the Section Organic Chemistry)
New 1,2,3-triazolium ionic liquid-supported chiral imidazolidinones were developed. The feasibility of the ionic liquid-supported imidazolidinones as chiral auxiliaries was demonstrated in sequential propionylation-alkylation-cleavage reactions, which provided the chiral product with good to excellent chemical yields (up to 90%) and high selectivities (up to 94% ee). The progress of the reactions could be monitored by TLC and NMR, and the ionic liquid-supported chiral auxiliaries could be recovered by simple extraction. View Full-Text
Keywords: ionic liquid; 1,2,3-triazolium; chiral imidazolidinone; asymmetric alkylation; chiral auxiliaries ionic liquid; 1,2,3-triazolium; chiral imidazolidinone; asymmetric alkylation; chiral auxiliaries
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MDPI and ACS Style

Jeong, Y.; Park, Y.; Ryu, J.-S. Synthesis of 1,2,3-Triazolium Ionic Liquid-Supported Chiral Imidazolidinones and Their Application in Asymmetric Alkylation Reaction. Molecules 2019, 24, 3349.

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