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A Novel Drug Design Strategy: An Inspiration from Encaging Tumor by Metallofullerenol [email protected]82(OH)22

1
CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences (CAS), Beijing 100049, China
2
College of Pharmacy, Shanxi Medical University, Taiyuan 030001, China
3
Jiangsu Key Laboratory of Hazardous Chemicals Safety and Control, College of Safety Science and Engineering, Nanjing Tech University, Nanjing 210009, China
*
Author to whom correspondence should be addressed.
Molecules 2019, 24(13), 2387; https://doi.org/10.3390/molecules24132387
Received: 9 June 2019 / Revised: 24 June 2019 / Accepted: 26 June 2019 / Published: 27 June 2019
Cancer remains a major threat to human health worldwide. Cytotoxicity has imposed restrictions on the conventional cytotoxic drug-based chemotherapy. The rapidly-developing nanomedicine has shown great promise in revolutionizing chemotherapy with improved efficiency and reduced toxicity. [email protected]82(OH)22, a novel endohedral metallofullerenol, was first reported by our research group to suppress tumor growth and metastasis efficiently without obvious toxicity. [email protected]82(OH)22 imprisons tumors by facilitating the formation of surrounding fibrous layers which is different from chemotherapeutics that poison tumor cells. In this review, the authors first reported the antineoplastic activity of metallofullerenol [email protected]82(OH)22 followed by further discussions on its new anti-cancer molecular mechanism—tumor encaging. On this basis, the unparalleled advantages of nanomedicine in the future drug design are discussed. The unique interaction modes of [email protected]82(OH)22 with specific targeted biomolecules may shed light on a new avenue for drug design. Depending on the surface characteristics of target biomolecules, nanomedicine, just like a transformable and dynamic key, can self-assemble into suitable shapes to match several locks for the thermodynamic stability, suggesting the target-tailoring ability of nanomedicine. View Full-Text
Keywords: metallofullerenol; [email protected]82(OH)22; encaging tumor; drug design; key and lock principle metallofullerenol; [email protected]82(OH)22; encaging tumor; drug design; key and lock principle
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MDPI and ACS Style

Li, J.; Chen, L.; Yan, L.; Gu, Z.; Chen, Z.; Zhang, A.; Zhao, F. A Novel Drug Design Strategy: An Inspiration from Encaging Tumor by Metallofullerenol [email protected]82(OH)22. Molecules 2019, 24, 2387. https://doi.org/10.3390/molecules24132387

AMA Style

Li J, Chen L, Yan L, Gu Z, Chen Z, Zhang A, Zhao F. A Novel Drug Design Strategy: An Inspiration from Encaging Tumor by Metallofullerenol [email protected]82(OH)22. Molecules. 2019; 24(13):2387. https://doi.org/10.3390/molecules24132387

Chicago/Turabian Style

Li, Jinxia; Chen, Linlin; Yan, Liang; Gu, Zhanjun; Chen, Zhaofang; Zhang, Aiping; Zhao, Feng. 2019. "A Novel Drug Design Strategy: An Inspiration from Encaging Tumor by Metallofullerenol [email protected]82(OH)22" Molecules 24, no. 13: 2387. https://doi.org/10.3390/molecules24132387

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