Next Article in Journal
Applying Nanoparticle Tracking Analysis to Characterize the Polydispersity of Aggregates Resulting from Tannin–Polysaccharide Interactions in Wine-Like Media
Next Article in Special Issue
Antispasmodic Activity of Prenylated Phenolic Compounds from the Root Bark of Morus nigra
Previous Article in Journal
Tales of the Unexpected: The Case of Zirconium(IV) Complexes with Desferrioxamine
Previous Article in Special Issue
The Role of Astragaloside IV against Cerebral Ischemia/Reperfusion Injury: Suppression of Apoptosis via Promotion of P62-LC3-Autophagy
Article Menu
Issue 11 (June-1) cover image

Export Article

Open AccessArticle

Encapsulated Microparticles of (1→6)-β-d-Glucan Containing Extract of Baccharis dracunculifolia: Production and Characterization

Chemistry Department, Universidade Estadual do Centro Oeste, Rua Simeão Varela de Sá, 03, Vila Carli, CEP, Guarapuava, PR 85040-080, Brazil
Chemistry Department, Universidade Tecnológica Federal do Paraná, Via do Conhecimento, Km 1, CEP, Pato Branco, PR 85503-390, Brazil
Department of Pathology, University of Louisville, 511 S. Floyd St, Louisville, KY 40292, USA
Chemistry Department, CCE, Universidade Estadual de Londrina, CEP, Londrina, PR 86057-970, Brazil
Programa de Pós-Graduação em Engenharia Ambiental, Universidade Tecnológica Federal do Paraná, Câmpus Londrina, CEP, Londrina, PR 86036-370, Brazil
Author to whom correspondence should be addressed.
Academic Editor: Tran Dang Xuan
Molecules 2019, 24(11), 2099;
Received: 6 May 2019 / Revised: 27 May 2019 / Accepted: 31 May 2019 / Published: 3 June 2019
(This article belongs to the Special Issue Discovery of Active Ingredients from Natural Products)
PDF [3720 KB, uploaded 3 June 2019]


β-Glucans are biomacromolecules well known, among other biological activities, for their immunomodulatory potential. Similarly, extracts of Baccharis dracunculifolia also possess biological properties and are used in folk medicine for the treatment of inflammation, ulcers, and hepatic diseases. Microparticles containing (1→6)-β-d-glucan (lasiodiplodan) and B. dracunculifolia extract were produced and characterized. A 23 factorial design was employed to define the conditions of production of microparticles by atomization. Lasiodiplodan associated with maltodextrin and gum arabic was studied as a matrix material. Microparticles of 0.4 μm mean size and high phenolics content (3157.9 μg GAE/g) were obtained under the optimized conditions. The microparticle size ranged from 0.23 to 1.21 µm, and the mathematical model that best represented the release kinetics of the extract was the Korsmeyer-Peppas model. Diffusional exponent (n) values of 0.64 at pH 7.7 and 1.15 at pH 2.61 were found, indicating particles with a non-Fickian or anomalous transport system, and Super Case II transport, respectively. Thermal analysis indicated that the microparticles demonstrated high thermal stability. The X-ray diffraction analyses revealed an amorphous structure, and HPLC-DAD analysis showed microparticles rich in phenolic compounds: caffeic acid, p-coumaric acid, and catechin. The microparticles obtained comprise a new biomaterial with biological potential for applications in different fields. View Full-Text
Keywords: bioactivity; encapsulation; experimental design; natural products bioactivity; encapsulation; experimental design; natural products

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Iurckevicz, G.; Dahmer, D.; Q. Santos, V.A.; Vetvicka, V.; M. Barbosa-Dekker, A.; F. H. Dekker, R.; Maneck Malfatti, C.R.; A. da Cunha, M.A. Encapsulated Microparticles of (1→6)-β-d-Glucan Containing Extract of Baccharis dracunculifolia: Production and Characterization. Molecules 2019, 24, 2099.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top