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Molecules 2018, 23(9), 2263; https://doi.org/10.3390/molecules23092263

Metal Chelating, Inhibitory DNA Damage, and Anti-Inflammatory Activities of Phenolics from Rambutan (Nephelium lappaceum) Peel and the Quantifications of Geraniin and Corilagin

1
Yunnan Institute of Food Safety, Kunming University of Science and Technology, No. 727 South Jingming Road, Kunming 650500, China
2
Inspection and Quarantine Technical Center of Weihai Entry-exit Inspection and Quarantine Bureau, Weihai 264205, China
3
Food Science and Technology, Ocean University of China, No. 5, Yushan Road, Qingdao 266005, China
The authors equally contributed to the paper.
*
Author to whom correspondence should be addressed.
Received: 1 August 2018 / Revised: 17 August 2018 / Accepted: 3 September 2018 / Published: 5 September 2018
(This article belongs to the Special Issue Discovery of Active Ingredients from Natural Products)
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Abstract

Whereas the preparation and biological properties of rambutan peel phenolics (RPP) were explored in our previous studies, the metal chelating, inhibitory DNA damage, and anti-inflammatory activities of RPP were evaluated and the important phenolics of RPP quantified in this study. Results showed that RPP had high Fe2+ and Cu2+-chelating activities with EC50 of 0.80 mg/mL and 0.13 mg/mL, respectively. RPP effectively decreased the production of hydroxyl radical with IC50 of 62.4 μg/mL. The protective effects of RPP against AAPH-induced DNA damage were also explored. RPP efficiently inhibited peroxyl radical-induced plasmid DNA strand breakage. The anti-inflammatory effects of RPP were determined using a lipopolysaccharide (LPS)-induced RAW 264.7 cell model. RPP significantly inhibited the production of nitric oxide (NO) and controlled the levels of inducible NO synthase mRNA in LPS-induced RAW 264.7 cells. The inhibitory activity increased in a dose-dependent manner. The above bioactivity of RPP was associated with its phenolic content and phenolic profiles. Furthermore, the contents of geraniin and corilagin in RPP were determined by an ultra-high performance liquid chromatography coupled with triple quadruple mass spectrometry (UPLC-QQQ-MS), showing 140.02 and 7.87 mg/g extract dry weight. Thus, RPP has potential applications as a novel nutraceutical and functional food in health promotion. View Full-Text
Keywords: rambutan peel phenolics; metal chelating; DNA damage protection; anti-inflammatory; geraniin rambutan peel phenolics; metal chelating; DNA damage protection; anti-inflammatory; geraniin
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Li, Y.; Li, Z.; Hou, H.; Zhuang, Y.; Sun, L. Metal Chelating, Inhibitory DNA Damage, and Anti-Inflammatory Activities of Phenolics from Rambutan (Nephelium lappaceum) Peel and the Quantifications of Geraniin and Corilagin. Molecules 2018, 23, 2263.

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