Next Article in Journal
Genome-Wide Identification and Characterization of Aquaporins and Their Role in the Flower Opening Processes in Carnation (Dianthus caryophyllus)
Previous Article in Journal
Comprehensive Snake Venomics of the Okinawa Habu Pit Viper, Protobothrops flavoviridis, by Complementary Mass Spectrometry-Guided Approaches
 
Search for Articles:
Title / Keyword
Author / Affiliation
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
Journals
Molecules
Volume 23
Issue 8
10.3390/molecules23081894
molecules-logo
Submit to this Journal Review for this Journal Edit a Special Issue
► Article Menu

Article Menu

share announcement thumb_up
...
textsms
...
Open AccessArticle

Effects of Mogrosides on High-Fat-Diet-Induced Obesity and Nonalcoholic Fatty Liver Disease in Mice

by
Xiaobing Zhang
1,2,
Yunfei Song
3,
Yipei Ding
1,2,
Wei Wang
4,5,
Ling Liao
4,5,
Jin Zhong
4,5,
Pengbo Sun
4,5,
Fan Lei
6,
Yaou Zhang
2,4,5 and
Weidong Xie
2,4,5,*
1
Department of Chemistry, Tsinghua University, Beijing 100084, China
2
State Key Laboratory of Chemical Oncogenomics, Graduate School at Shenzhen, Tsinghua University, Shenzhen, China
3
Guilin Layn Natural Ingredients Corp., Guilin 541100, China
4
Open FIESTA Center, Tsinghua University, Shenzhen 518055, China
5
Key Lab in Healthy Science and Technology, Division of Life Science, Graduate School at Shenzhen; Tsinghua University, Shenzhen 518055, China
6
Laboratory of Pharmaceutical Science, School of Life Science, School of Medicine, Tsinghua University, Beijing 100084, China
*
Author to whom correspondence should be addressed.
Molecules 2018, 23(8), 1894; https://doi.org/10.3390/molecules23081894
Received: 12 July 2018 / Revised: 26 July 2018 / Accepted: 28 July 2018 / Published: 29 July 2018
(This article belongs to the Section Natural Products Chemistry)
View Full-Text Download PDF
Browse Figures

Abstract

Obesity and nonalcoholic fatty liver disease (NAFLD) are highly prevalent and cause numerous metabolic diseases. However, drugs for the prevention and treatment of obesity and NAFLD remain unavailable. In this study, we investigated the effects of mogrosides (luo han guo, LH) in Siraitia grosvenorii saponins on high-fat-diet-induced obesity and NAFLD in mice. We found that compared with the negative control, LH reduced body and liver weight. LH also decreased fat accumulation and increased AMP-activated protein kinase (AMPK) phosphorylation (pAMPK) levels in mouse livers. We also found that high-purity mogroside V upregulated pAMPK expression in HepG2 cells. In addition, high-purity mogroside V inhibited reactive oxygen species production and upregulated sequestosome-1 (SQSTM1, p62) expression in THP-1 cells. These results suggest that LH may affect obesity and NAFLD by enhancing fat metabolism and antioxidative defenses. Mogroside V may be a main component of LH. However, the exact molecular mechanisms and active components responsible for the inhibitory effects of LH on obesity and NAFLD require further investigation. View Full-Text
Keywords: Siraitia grosvenorii; mogrosides; obesity; nonalcoholic fatty liver disease; AMPK; p62 Siraitia grosvenorii; mogrosides; obesity; nonalcoholic fatty liver disease; AMPK; p62
►▼ Show Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
SciFeed

Share and Cite

MDPI and ACS Style

Zhang, X.; Song, Y.; Ding, Y.; Wang, W.; Liao, L.; Zhong, J.; Sun, P.; Lei, F.; Zhang, Y.; Xie, W. Effects of Mogrosides on High-Fat-Diet-Induced Obesity and Nonalcoholic Fatty Liver Disease in Mice. Molecules 2018, 23, 1894. https://doi.org/10.3390/molecules23081894

AMA Style

Zhang X, Song Y, Ding Y, Wang W, Liao L, Zhong J, Sun P, Lei F, Zhang Y, Xie W. Effects of Mogrosides on High-Fat-Diet-Induced Obesity and Nonalcoholic Fatty Liver Disease in Mice. Molecules. 2018; 23(8):1894. https://doi.org/10.3390/molecules23081894

Chicago/Turabian Style

Zhang, Xiaobing; Song, Yunfei; Ding, Yipei; Wang, Wei; Liao, Ling; Zhong, Jin; Sun, Pengbo; Lei, Fan; Zhang, Yaou; Xie, Weidong. 2018. "Effects of Mogrosides on High-Fat-Diet-Induced Obesity and Nonalcoholic Fatty Liver Disease in Mice" Molecules 23, no. 8: 1894. https://doi.org/10.3390/molecules23081894

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Metrics

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop