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Molecules 2018, 23(7), 1814; https://doi.org/10.3390/molecules23071814

The Use of Juçara (Euterpe edulis Mart.) Supplementation for Suppression of NF-κB Pathway in the Hypothalamus after High-Fat Diet in Wistar Rats

1
Programa de Pós-Graduação Interdisciplinar em Ciências da Saúde, Universidade Federal de São Paulo, São Paulo 11015-020, Brazil
2
Departamento de Biociências, Universidade Federal de São Paulo, São Paulo 11015-020, Brazil
3
Departamento de Fisiologia, Universidade Federal de São Paulo, São Paulo 04023-062, Brazil
4
Laboratório de Nutrição e Fisiologia Endócrina (LaNFE); Departamento de Biociências, Instituto de Saúde e Sociedade, Universidade Federal de São Paulo, Rua Silva Jardim, 136, Térreo, Vila Mathias, Santos, São Paulo 11015-020, Brazil
*
Author to whom correspondence should be addressed.
Academic Editor: Margarida Castell Escuer
Received: 12 June 2018 / Revised: 17 July 2018 / Accepted: 18 July 2018 / Published: 21 July 2018
(This article belongs to the Special Issue Natural Polyphenols and Health)
Full-Text   |   PDF [843 KB, uploaded 21 July 2018]   |  

Abstract

Obesity is associated with modern diets that are rich in saturated fatty acids. These dietary patterns are linked to low-grade proinflammatory mechanisms, such as the toll-like receptor 4/nuclear factor kappa-B (NF-κB) pathway rapidly activated through high-fat diets. Juçara is a berry rich in anthocyanins and unsaturated fatty acids, which prevents obesity and associated comorbidities. We evaluated the effect of different doses of freeze-dried juçara pulp on NF-κB pathway after the consumption of short-term high-fat diet. Male Wistar rats with ad libitum access to food and water were divided into four groups: Control diet (C), high-fat diet (HFC), high-fat diet with 0.25% juçara (HFJ 0.25%), and high-fat diet with 0.5% juçara (HFJ 0.5%). Energy intake and body weight gain were increased in HFC and HFJ 0.5% groups compared to C group. The hypothalamus weight reduced in the HFC group compared to C and HFJ 0.25% groups. Cytokines, MYD88, TRAF6, and pNF-κBp50 levels in the hypothalamus, serum triacylglycerol, LDL-cholesterol (LDL-C), and free fatty acid levels were improved in the HFJ 0.25% group. In summary, the HFJ 0.25% group had better protective effects than those in the HFJ 0.5%. Therefore, 0.25% juçara can be used to protect against central inflammation through the high-fat diet-induced NF-κB pathway. View Full-Text
Keywords: juçara; inflammation; hypothalamus; short-term high-fat diet; NF-κB pathway juçara; inflammation; hypothalamus; short-term high-fat diet; NF-κB pathway
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Santamarina, A.B.; Jamar, G.; Mennitti, L.V.; de Rosso, V.V.; Cesar, H.C.; Oyama, L.M.; Pisani, L.P. The Use of Juçara (Euterpe edulis Mart.) Supplementation for Suppression of NF-κB Pathway in the Hypothalamus after High-Fat Diet in Wistar Rats. Molecules 2018, 23, 1814.

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